Efeitos adversos da toxina botulínica sobre parâmetros ósseos e musculares: revisão integrativa da literatura
DOI:
https://doi.org/10.21270/archi.v10i6.5012Palavras-chave:
Toxinas Botulínicas Tipo A, Osso, Músculos MastigatóriosResumo
Introdução: A toxina botulínica do tipo A tem sido utilizada amplamente como opção terapêutica para o bruxismo. Todavia, é importante discutir o seu efeito nos parâmetros ósseos e musculares. Objetivo: Conhecer, através de revisão integrativa de literatura, os possíveis efeitos adversos da administração terapêutica da toxina botulínica sobre parâmetros ósseos e musculares em modelos animais e humanos. Método: Foi realizada uma busca por artigos nas bases de dados Lilacs, PubMed, Scielo e Google Acadêmico, tendo como descritores os termos “botulinum toxin and bone and masticatory muscles”, na língua inglesa e os termos toxina botulínica e osso e músculos mastigatórios, em português. A inclusão dos artigos nesta revisão obedeceu a critérios de inclusão e exclusão. Resultados: Foram encontrados 283 artigos nas bases de dados consultadas, sendo 261 artigos excluídos por título, e nenhum artigo foi excluído por resumoe após sua leitura na íntegra. Um total de 22 artigos fizeram parte desta revisão. Conclusão: Estudos em ratos apontam para alterações esqueléticas e musculares após administração da BTX-A, mesmo comuso único, o que pode resultar em perda óssea a curto e longo prazo e, assim, potencializar problemas futuros. Mais estudos controlados randomizados deveriam ser realizados em humanos para melhores esclarecimentos sobresos efeitos da BTX-A nas estruturas ósseas.
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