Clinical and Histopathological Profile of Benign Neoplasms of the Salivary Glands in Patients Diagnosed in a Reference Service in the State of Amazonas
DOI:
https://doi.org/10.21270/archi.v12i1.6025Keywords:
Diagnosis, Salivary Glands, NeoplasmsAbstract
Introduction: Salivary gland neoplasms represent some of the main causes of involvement of the stomatognathic system, being characterized by lesions exclusive to the oral region, found in the form of tumors. Tumors are uncommon lesions that, depending on the biological behavior, vary from benign to malignant lesions, affecting the major and minor salivary glands. Objective: To trace the clinical and histopathological profile of benign salivary gland neoplasms diagnosed in a reference service in the State of Amazonas over a period of 15 years. Materials and methods: Reports of patients who underwent biopsy were used as the study population, using elaborated record sheets as an aid for data collection, which were used for tabulation and data analysis. Results: The sample consisted of 35 patients diagnosed with benign salivary gland neoplasia. The parotid gland and the hard palate region were the most predisposed sites and the most prevalent benign lesion was the pleomorphic adenoma, mainly in women, in the third decade of life. Conclusion: The microscopic variety demonstrates the histopathological diversity of these lesions and are important for the knowledge of salivary gland neoplasms in the local population, in addition to serving as a basis for elaborating the diagnostic hypothesis in cases of suspected benign tumors, helping in the clinical management, treatment and patient prognosis.
Downloads
References
Lin HH, Limesand KH, Ann DK. Current State of Knowledge on Salivary Gland Cancers. Crit Rev Oncog. 2018;23(3-4):139-51.
Bath-Balogh M, Fehrenbach MJ. Anatomia, Histologia e Embriologia dos dentes e das estruturas orofaciais. 3.ed. São Paulo: Elsevier; 2012
Maruya S, Shirasaki T, Nagaki T, Kakehata S, Kurotaki H, Mizukami H, et al. Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications. BMC Cancer. 2009;9:72.
Morais MLSA. Morais M de LS de A. Estudo clinicopatologico das neoplasias benignas e malignas de glândulas salivares maiores e menores [tese]. Natal-RN: Universidade Federal do Rio Grande do Norte (UFRN); 2011.
Bradley PJ, Wittekindt C. Classification of Benign Salivary Neoplasms. Pocket Dentistry. 2016.
Cotran RS, Kumar V, Robbins SL. Robbins and Cotran Pathologic Basis of Disease. 9.ed. Philadelphia, Pa: Elsevier; 2015.
Stryjewska-Makuch G, Kolebacz B, Janik MA, Wolnik A. Increase in the incidence of parotid gland tumors in the years 2005-2014. Otolaryngol Pol. 2017;71(2):29-34.
Sentani K, Ogawa I, Ozasa K, Sadakane A, Utada M, Tsuya T et al. Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years. J Clin Med. 2019;8(5):566.
Pouloudi D, Sotiriadis A, Theodorakidou M, Sarantis P, Pergaris A, Karamouzis MV et al. The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors. Int J Mol Sci. 2020, 21(24), 9335
Wyngaarden JB, Smith Jr LH; Bennett JC. Cecil Textbook of Medicine. 19. ed. Philadelphia: WB Saunders Co; 1992.
INCA - Instituto Nacional de Câncer. Estimativa 2020: incidência de câncer no Brasil. INCA - Instituto Nacional de Câncer. 2019.
Mejía-Velázquez CP, Durán-Padilla MA, Gómez-Apo E, Quezada-Rivera D, Gaitán-Cepeda LA. Tumors of the salivary gland in Mexicans. A retrospective study of 360 cases. Med Oral Patol Oral Cir Bucal. 2012;17(2):e183-9
Bittar RF. Neoplasia das glândulas salivares: estudo envolvendo a análise de 727 biópsias realizadas no período de 1995 a 2013. Rev Científica. 2020;7(1):8-13.
Xavier JC, Andrade SC, Arcoverde CAL, Lucena KCR, Cavalcanti UDNT, Carvalho AAT. Levantamento epidemiológico das lesões bucais apresentadas por pacientes atendidos no serviço de Estomatologia da Universidade Federal de Pernambuco durante o período de janeiro de 2006 a julho de 2008. IJD. 2009;8(3).
Ogawa A, Eidy Takemoto L, De Lima Navarro P, Heshiki R. Salivary Glands Neoplasms. Int Arch Otorhinolaryngol. Intl Arch Otorhinolaryngol. 2008;12(3):409-18.
Bettio A, Salgado G, Azevedo-Alanis LR, Machado MÂN, Gregio AMT, Lima AAS. Prevalência das lesões de glândulas salivares em laudos histopatológicos do Laboratório de Patologia Experimental da PUCPR no período de 1999-2008. RSBO. 2009;6(3):231-36.
Santos GC, Martins MR, Pellacani LB, Vieira ACT, Nascimento LA, Abrahão M. Neoplasias de glândulas salivares: estudo de 119 casos. J Bras Patol Med Labor. 2003;39(4):371-75.
Skálová A, Hyrcza MD, Leivo I. Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands. Head Neck Pathol. 2022;16(1):40-53.
Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017;11(1):68-77.
Seethala RR, Stenman G. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. Head Neck Pathol. 2017;11(1):55-67.
UFAC. Universidade Federal do Acre. Neoplasia — Universidade Federal do Acre Patologia Geral. 2018.
Fu JY, Wu CX, Shen SK, Zheng Y, Zhang CP, Zhang ZY. Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology. BMC Cancer. 2019;19(1):350.
Singh M, Sagar N, Yadav S, Aggarwal R, Mandal S, Khurana N, Jain S, Meher R. Utility of Fine Needle Aspiration in Diagnosis of Intraoral Minor Salivary Gland Tumors. J Cytol. 2020;37(1):53-7.
Maahs GS, Oppermann P de O, Maahs LGP, Machado Filho G, Ronchi AD. Parotid gland tumors: a retrospective study of 154 patients. Braz j otorhinolaryngol. 2015;81(3):301-6.
Torabinia N, Khalesi S. Clinicopathological study of 229 cases of salivary gland tumors in Isfahan population. Dent Res J (Isfahan). 2014;11(5):559-63.
Melo AUC de, Agripino GG, Ribeiro CF, Martins FAP, Aragão M do S, Rosa MRD da. Neoplasias de Glândulas Salivares: Estudo Retrospectivo de 134 casos numa população do Nordeste do Brasil. Rev cir traumatol buco-maxilo-fac. 2012;12(2):65-72.
Lima SS, Soares AF, de Amorim RF, Freitas Rde A. Perfil epidemiológico das neoplasias de glândulas salivares: análise de 245 casos [Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases]. Braz J Otorhinolaryngol. 2005;71(3):335-40.
Silva TF de A, Souza RB de, Rocha RD, Araújo FA da C, Morais HHA de. Levantamento das Biópsias Realizadas no Serviço de Cirurgia Buco-Maxilo-Facial do Curso de Odontologia da Universidade do Estado do Rio Grande do Norte. Rev cir traumatol buco-maxilo-fac. 2011; 11(2):91-100.
Boraks S. Semiotécnica, Diagnóstico e Tratamento das Doenças da Boca. São Paulo: Artes Médicas; 2013.
Oliveira ASB. Muscle biopsy with different levels of histological sections: an old procedure as a “still modern” approach. J Bras Patol Med Lab. 2017;53(3):148-49.
Cho JK, Lim BW, Kim EH, Ko YH, Oh D, Noh JM et al. Low-Grade Salivary Gland Cancers: Treatment Outcomes, Extent of Surgery and Indications for Postoperative Adjuvant Radiation Therapy. Ann Surg Oncol. 2016;23(13):4368-375.
Khanal P. Pleomorphic Adenoma of the Submandibular Gland: A Case Report. JNMA J Nepal Med Assoc. 2019;57(215):53-5.
Yousra Z, Saliha C. Pleomorphic adenoma of hard palate: a case report. Pan Afr Med J. 2021;38:146.
Karthik RS, Sivakumar JS, Cholan R, Shanmugapriya, Rajan VS, Moorthy MS et al. Myoepithelioma. J Pharm Bioallied Sci. 2015;7(Suppl 2):S779-81.
Quer M, Hernandez-Prera JC, Silver CE, Casasayas M, Simo R, Vander Poorten V et al. Current Trends and Controversies in the Management of Warthin Tumor of the Parotid Gland. Diagnostics (Basel). 2021;11(8):1467.
Neville BW, Damm DD, Allen CM, Chi AC. Oral & Maxillofacial Pathology. St. Louis: Elsevier; 2016.
Regezi JA, Sciubba JJ, Jordan RCK. Oral pathology: clinical pathologic correlations. St. Louis: Elsevier; 2017.
Alali F, Kochaji N. Proliferative Activity of Myoepithelial Cells in Normal Salivary Glands and Adenoid Cystic Carcinomas Based on Double Immunohistochemical Labeling. Asian Pac J Cancer Prev. 2018;19(7):1965-970.
Carraro G, Stripp BR. Roles for Myoepithelial Cells in the Formation and Maintenance of Submucosal Glands. Am J Respir Cell Mol Biol. 2017;56(6):685-86.
Chen CY, Shen JQ, Wang F, Wan R, Wang XP. Prognostic significance of annexin A1 expression in pancreatic ductal adenocarcinoma. Asian Pac J Cancer Prev. 2012;13(9):4707-12.
Togarrati PP, Dinglasan N, Desai S, Ryan WR, Muench MO. CD29 is highly expressed on epithelial, myoepithelial, and mesenchymal stromal cells of human salivary glands. Oral Dis. 2018;24(4):561-72.
Maria OM, Maria SM, Redman RS, Maria AM, Saad El-Din TA, Soussa EF et al. Effects of double ligation of Stensen's duct on the rabbit parotid gland. Biotech Histochem. 2014;89(3):181-98.
Holmberg KV, Hoffman MP. Anatomy, biogenesis and regeneration of salivary glands. Monogr Oral Sci. 2014;24:1-13.
Torres R, Motta Junior J, Oliveira MV, Martins VB, Albuquerque GC. Mioeptelioma de glândula salivar menor em palato relato de caso. J Bras Coll Oral Maxillofac Surg. 2019;5(3):51-5.
Lee DH, Yoon TM, Lee JK, Lim SC. Surgical treatment strategy in Warthin tumor of the parotid gland. Braz. j. otorhinolaryngol. 2019;85(5):546-50.
Israel Y, Rachmiel A, Gourevich K, Nagler R. Survival Probabilities Related to Histology, Grade and Stage in Patients With Salivary Gland Tumors. Anticancer Res. 2019;39(2):641-47.
