Prevalence of Patients with Comorbidities at the Undergraduate Clinic of Piracicaba Dental School – Brazil


  • Beatriz Mazzo Department of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)
  • Victor Augusto Benedicto dos Santos Department of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)
  • Sidney Figueroba Department of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)
  • Adriana de Jesus Soares Endodontics Division, Department of Restorative Dentistry, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)
  • Guilherme Elias Pessanha Henriques Department of Prosthodontics and Periodontology, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)
  • Thomas Barbin Department of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)
  • Francisco Carlos Groppo Department of Biosciences, Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)



Diabetes Mellitus, Hypertension, Heart Diseases, Endocrine System Diseases, Hematologic Diseases


Objectives: The aim of this study was to evaluate the prevalence of comorbidities in patients treated at the FOP-UNICAMP undergraduate clinic. A survey based on patient records obtained between June 2021 and November 2022 was conducted. Comorbidities, such as hypertension, diabetes, and heart diseases, among others, were identified. Additionally, dental history, gender, and age were assessed. Methods: The data were analyzed using chi-square and Mann-Whitney tests. A total of 2.857 medical records were included in the study. Results: There were no significant differences (p=0.12) in the ages (median; 1st and 3rd quartiles) between females (49.6; 36.3 - 60.1 years) and males (50.4; 35 - 62.5 years). However, there was a significantly higher number of females (n=1716) compared to males (n=1141) (p<0.0001), and the majority of patients fell into the 35-65 years age group (n=1676). There was a higher proportion of females under medical treatment or with comorbidities, and these patients were older compared to others (p<0.0001). There were no significant differences (p>0.05) between genders in relation to cardiovascular diseases (M=116; F=170), hypertension (M=320; F=510), diabetes (M=153; F=225), or the combination of these diseases. Hypertension was the most prevalent condition (29.1%). The patients with these diseases were older (p<0.0001) compared to those without these conditions. Depression and/or anxiety were more common in females and older patients. Conclusions: In conclusion, there was a higher proportion of comorbidities in females, and age was higher in individuals with comorbidities.


Não há dados estatísticos.


Watt RG, Serban S. Multimorbidity: a challenge and opportunity for the dental profession. Br Dent J. 2020;229(5):282-286. doi:10.1038/s41415-020-2056-y

Whitty CJM, MacEwen C, Goddard A, et al. Rising to the challenge of multimorbidity. BMJ. 2020;368:l6964. doi:10.1136/bmj.l6964

Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426-440. doi:10.1038/s41577-020-00488-6

Lechleitner M. Obesity and the metabolic syndrome in the elderly--a mini-review. Gerontology. 2008;54(5):253-259. doi:10.1159/000161734

Lellis JBM, Borges T de F, de Oliveira RH, et al. Does Systemic Arterial Hypertension Change the Function of the Stomatognathic System? Prague Med Rep. 2021;122(3):201-211. doi:10.14712/23362936.2021.17

Yang G, Tan Z, Zhou L, et al. Effects of Angiotensin II Receptor Blockers and ACE (Angiotensin-Converting Enzyme) Inhibitors on Virus Infection, Inflammatory Status, and Clinical Outcomes in Patients With COVID-19 and Hypertension: A Single-Center Retrospective Study. Hypertens Dallas Tex 1979. 2020;76(1):51-58. doi:10.1161/HYPERTENSIONAHA.120.15143

Ide K, Seto K, Usui T, Tanaka S, Kawakami K. Correlation between dental conditions and comorbidities in an elderly Japanese population: A cross-sectional study. Medicine (Baltimore). 2018;97(24):e11075. doi:10.1097/MD.0000000000011075

Souza KC de, Queiroz ARG de A, Dias RB, Siqueira DV da S, Leitão TF de O, Silva VDU e. Prevalência das alterações sistêmicas dos pacientes atendidos pela Clínica de Odontologia do Centro Universitário Ruy Barbosa. Arch Health Investig. 2021;10(8):1225-1230. doi:10.21270/archi.v10i8.5094

Ahlqvist E, Storm P, Käräjämäki A, et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 2018;6(5):361-369. doi:10.1016/S2213-8587(18)30051-2

Ko KI, Sculean A, Graves DT. Diabetic wound healing in soft and hard oral tissues. Transl Res J Lab Clin Med. 2021;236:72-86. doi:10.1016/j.trsl.2021.05.001

Zhao D, Zhen Z, Pelekos G, Yiu KH, Jin L. Periodontal disease increases the risk for onset of systemic comorbidities in dental hospital attendees: An 18-year retrospective cohort study. J Periodontol. 2019;90(3):225-233. doi:10.1002/JPER.18-0224

Ziebolz D, Reiss L, Schmalz G, Krause F, Haak R, Mausberg RF. Different views of dentists and general medical practitioners on dental care for patients with diabetes mellitus and coronary heart diseases: results of a questionnaire-based survey in a district of Germany. Int Dent J. 2018;68(3):197-203. doi:10.1111/idj.12353

Apoorva SM, Sridhar N, Suchetha A. Prevalence and severity of periodontal disease in type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus) patients in Bangalore city: An epidemiological study. J Indian Soc Periodontol. 2013;17(1):25-29. doi:10.4103/0972-124X.107470

Rydén L, Buhlin K, Ekstrand E, et al. Periodontitis Increases the Risk of a First Myocardial Infarction. Circulation. 2016;133(6):576-583. doi:10.1161/CIRCULATIONAHA.115.020324

Schneider C, Zemp E, Zitzmann NU. Oral health improvements in Switzerland over 20 years. Eur J Oral Sci. 2017;125(1):55-62. doi:10.1111/eos.12327

Müller F, Srinivasan M, Krause KH, Schimmel M. Periodontitis and peri-implantitis in elderly people experiencing institutional and hospital confinement. Periodontol 2000. 2022;90(1):138-145. doi:10.1111/prd.12454

Piedade EFS, Gulinelli JL, Queiroz TP, Rosa VM, Santos PL. Surgical complications in systemically compromised patients: analysis of 992 medical records. RGO - Rev Gaúcha Odontol. 2020;68:e20200031. doi:10.1590/1981-863720200003120190005

Kolte VS, Dolas RS, Shenoi R. Demographic study of prevalence of systemic diseases in oral maxillofacial surgery patients of central India. J Maxillofac Oral Surg. 2014;13(3):267-270. doi:10.1007/s12663-013-0533-4

López R, Smith PC, Göstemeyer G, Schwendicke F. Ageing, dental caries and periodontal diseases. J Clin Periodontol. 2017;44(S18):S145-S152. doi:10.1111/jcpe.12683

Gadelha L de A, Capalbo-da-Silva R, Lima VN de de, Momesso GAC, Queiroz SBF de, Souza FÁ. Prevalência de doenças sistêmicas entre os pacientes atendidos na Clínica Odontológica da Faculdade Católica Rainha do Sertão no município de Quixadá-CE. Arch Health Investig. 2017;6(7). doi:10.21270/archi.v6i7.2022

Oliveira MMMB de, Cerqueira A, Freitas VS, Freitas M guiar de. Prevalência de indivíduos portadores de doenças de base numa clínica de extensão em cirurgia bucal: estudo preliminar. Stomatos. 2006;12(22):35-41.

Dash G, Mishra L, Singh NR, et al. Prevalence and Quality of Endodontic Treatment in Patients with Cardiovascular Disease and Associated Risk Factors. J Clin Med. 2022;11(20):6046. doi:10.3390/jcm11206046

Walther C, Wenzel JP, Schnabel RB, et al. Association between periodontitis and heart failure in the general population. ESC Heart Fail. 2022;9(6):4189-4197. doi:10.1002/ehf2.14150

Guggenheimer J, Bilodeau EA, Barket SJ. Medical conditions and medication use in a U.S. dental school clinic population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(4):379-384. doi:10.1016/j.oooo.2014.12.016

Marta SN, Matsumoto MS, Gatti MA, De Conti MH, De Ap Simeão SF, De Oliveira Braga Franzolin S. Determinants of Demand in the Public Dental Emergency Service. J Contemp Dent Pract. 2017;18(2):156-161. doi:10.5005/jp-journals-10024-2008

Thomas DC, Khan J, Manfredini D, Ailani J. Temporomandibular Joint Disorder Comorbidities. Dent Clin North Am. 2023;67(2):379-392. doi:10.1016/j.cden.2022.10.005

Goldstein RB, Dawson DA, Chou SP, Grant BF. Sex differences in prevalence and comorbidity of alcohol and drug use disorders: results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. J Stud Alcohol Drugs. 2012;73(6):938-950. doi:10.15288/jsad.2012.73.938

Fonseca HAR, Izar MCO, Drager LF, et al. Primary Prevention of Cardiovascular Disease at Community Clinics in the State of Sao Paulo, Brazil: Results from the Epidemiological Information Study of Communities. Glob Heart. 2023;18(1):24. doi:10.5334/gh.1203

Fernández-Feijoo J, Núñez-Orjales JL, Limeres-Posse J, Pérez-Serrano E, Tomás-Carmona I. Screening for hypertension in a primary care dental clinic. Med Oral Patol Oral Cirugia Bucal. 2010;15(3):e467-472. doi:10.4317/medoral.15.e467

Argyropoulou OD, Valentini E, Ferro F, et al. One year in review 2018: Sjögren’s syndrome. Clin Exp Rheumatol. 2018;36 Suppl 112(3):14-26.

Helms JB dos S, Barbosa CA, Abrahão AC, Cabral MG, Bica BERG, Torres SR. Are salivary flow rates associated with histopathologic aspects in patients with rheumatoid arthritis? Braz Oral Res. 2022;36:e0120. doi:10.1590/1807-3107bor-2022.vol36.0120

Thornhill MH, Gibson TB, Yoon F, et al. Antibiotic Prophylaxis Against Infective Endocarditis Before Invasive Dental Procedures. J Am Coll Cardiol. 2022;80(11):1029-1041. doi:10.1016/j.jacc.2022.06.030

Abe K, Ishikawa Y, Kita Y, et al. Association of low-dose glucocorticoid use and infection occurrence in systemic lupus erythematosus patients: a prospective cohort study. Arthritis Res Ther. 2022;24(1):179. doi:10.1186/s13075-022-02869-9

Kazemipoor M, Vatanchian MK, Jambarsang S, Owlia F. Evaluation of the Response to Pulpal Sensibility Tests (Cold, EPT) in Anemic and Healthy Women. Int J Dent. 2022;2022:3518817. doi:10.1155/2022/3518817

Mulimani P, Ballas SK, Abas ABL, Karanth L. Treatment of dental complications in sickle cell disease. Cochrane Database Syst Rev. 2016;4:CD011633. doi:10.1002/14651858.CD011633.pub2

Alrayyes S, Baghdan D, Haddad RY, et al. Sickle cell disease; An overview of the disease and its systemic effects. Dis--Mon DM. 2018;64(6):283-289. doi:10.1016/j.disamonth.2017.12.003

Gusmini MADS, De Sa AC, Feng C, Arany S. Predictors of dental complications post-dental treatment in patients with sickle cell disease. Clin Exp Dent Res. 2021;7(1):11-19. doi:10.1002/cre2.335

Sassarini DJ. Depression in midlife women. Maturitas. 2016;94:149-154. doi:10.1016/j.maturitas.2016.09.004

Sander J, Moessner M, Bauer S. Depression, Anxiety and Eating Disorder-Related Impairment: Moderators in Female Adolescents and Young Adults. Int J Environ Res Public Health. 2021;18(5):2779. doi:10.3390/ijerph18052779

Chang-Quan H, Xue-Mei Z, Bi-Rong D, Zhen-Chan L, Ji-Rong Y, Qing-Xiu L. Health status and risk for depression among the elderly: a meta-analysis of published literature. Age Ageing. 2010;39(1):23-30. doi:10.1093/ageing/afp187



Como Citar

Mazzo, B., dos Santos, V. A. B., Figueroba, S., Soares, A. de J., Henriques, G. E. P., Barbin, T., & Groppo, F. C. (2024). Prevalence of Patients with Comorbidities at the Undergraduate Clinic of Piracicaba Dental School – Brazil. ARCHIVES OF HEALTH INVESTIGATION, 13(1), 24–32.



Original Articles