Association between Antimicrobial Photodyamic Therapy and Nanotechnology: A Systematic Review and Meta-analysis
DOI:
https://doi.org/10.21270/archi.v12i1.5816Keywords:
Nanotechnology, Photochemotherapy, Dentistry, MicrobiologyAbstract
Antimicrobial photodynamic therapy (aPDT) has been presented as a highly efficient complementary therapy in the dental treatment context. Different specialties have been benefited from this therapy as a microbial load reduction factor. Recently, the association between this therapy and the use of nanoparticles and nanotechnology has been suggested. Thus, this systematic review sought to assess the general outcome of this association, in the dental treatment context. A search was performed in eight virtual databases, eligibility criteria were established according to the PICO strategy, and a PRISMA flowchart was created to present the selection of the narrative and quantitative sample. Out of 930 results, 27 were selected for narrative synthesis and 4 for quantitative. The risk of bias was accessed through an adaptation of the SYRCLE tool, and a table was created grouping the data of interest for the summaries. The most incident design was in vitro assays, in which different protocols for the use of aPDT were also perceived, and a wide variety of associated nanotechnologies. The risk of bias pointed to some inconclusive answers, due to the SYRCLE tool itself and its deficient relationship with the different designs included. The narrative synthesis and the quantitative synthesis showed a favorable outcome for the association between aPDT and nanotechnology, especially in the reduction of endodontic and periodontal microorganisms of interest, common in cases of persistent and/or recurrent infections. However, even with promising results, further studies are needed to bring the necessary robustness to the inference of this satisfactory relationship to clinical dental practice.
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