A eficácia da terapia fotodinâmica no tratamento periodontal não cirúrgico
DOI:
https://doi.org/10.21270/archi.v6i6.2072Resumo
Introdução: A periodontia é uma especialidade odontológica que visa promover a saúde dos tecidos periodontais através do controle dos agentes etiológicos das periodontopatogenias, os microrganismos. Apesar da raspagem e alisamento coronoradicular consistir em um tratamento mecânico bastante utilizado, tal terapia não consegue proporcionar o controle dos patógenos nas áreas de difíceis instrumentação, motivo pelo qual torna-se necessário a utilização de terapias complementares que reduzam os redutos bacterianos em locais inacessíveis aos instrumentos periodontais. Objetivo: Relatar informações sobre o mecanismo de ação, aplicabilidade e eficácia da terapia fotodinâmica no tratamento periodontal não cirúrgico. Material e método: Foi realizado uma revisão de literatura conduzida através do acesso às bases de dados eletrônicas Pubmed, Scielo e Lilacs e Periódicos Capes. Como estratégica de busca utilizou-se as palavras chaves “Laser”, “Photodynamic Therapy” e “Periodontal Disease”. Resultados: Redução bacteriana e efeitos colaterais mínimos são vantagens atribuídas à terapia fotodinâmica, no entanto, a literatura evidencia estudos que apresentam resultados controversos quanto ao efeito adicional da terapia fotodinâmica no tratamento periodontal. Conclusão: É necessária a padronização dos protocolos empreendidos para que se obtenha dados mais esclarecedores sobre a eficácia da terapia fotodinâmica no tratamento periodontal não cirúrgico.Descritores: Fotoquimioterapia; Lasers; Terapia com Luz de Baixa Intensidade; Doenças Periodontais; Periodontia.
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Referências
Malik R, Manocha A, Suresh, DK. Photodynamic therapy-A strategic review. Indian J Dent Res. 2010; 21(2):285-91.
Loos BG, John RP, Laine ML. Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodonto. 2005; 32(6):159-79.
Herrera D, Alonso B, León R, Roldán S, Sanz M. Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. J Clin Periodonto. 2008; 35(8 Suppl):45-66.
Ishikawa I, Aoki A, Takasaki AA, Mizutani K, Sasaki KM, Izumi,Y. Application of lasers in periodontics: true innovation or myth? Periodontology. 2009;50(1):90-126.
Tsai CY, Tang CY, Tan TS, Chen KH, Liao KH, Liou ML. Subgingival microbiota in individuals with severe chronic periodontitis. Braz. J Microbiol Immunol Infect. 2016; 4(3):1-9.
Rajesh S, Koshi E, Philip K, Mohan A. Antimicrobial photodynamic therapy: An overview. J Indian Soc Periodontol. 2011; 15(4): 323-7.
Fernandes LA, De Almeida JM, Theodoro LH, Bosco AF, Nagata MJH, Martins TM, et al. Treatment of experimental periodontal disease by photodynamic therapy in immunosuppressed rats. J Clin Periodonto. 2009; 36(3):219-28.
Luchesi VH, Pimentel S, Kolbe MF, Ribeiro F, Casarin RC, Nociti FH, et al. Photodynamic therapy in the treatment of class II furcation: a randomized controlled clinical trial. J Clin Periodonto. 2013;40(8):781-88.
Harris F, Chatfield LK, Phoenix, DA. Phenothiazinium based photosensitisers-photodynamic agents with a multiplicity of cellular targets and clinical applications. Curr Drug Targets. 2005; 6(5):615-27.
Schwarz F, Aoki A, Becker J, Sculean A. Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodonto. 2008; 35(8 Suppl): 29-44.
Al Habashneh R, Asa'ad FA, Khader Y. Photodynamic therapy in periodontal and peri-implant diseases. Quintessence Int. 2015; 46(8):670-7.
Arweiler NB, Pietruska M, Pietruski J, Skurska A, Dolińska E, Heumann C, et al. Six-month results following treatment of aggressive periodontitis with antimicrobial photodynamic therapy or amoxicillin and metronidazole. Clin Oral Investig. 2014; 18(9):2129-35.
Haffajee AD, Torresyap G, Socransky, SS. Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. J Clin Periodonto. 2007; 34(3):243-53.
Ryder MI. An update on HIV and periodontal disease. J. Periodontol. 2002; 73(9):1071-8.
Azarpazhooh A, Shah PS, Tenenbaum HC, Goldberg MB. The effect of photodynamic therapy for periodontitis: a systematic review and meta-analysis. J. Periodontol. 2010; 81(1):4-14.
Balata ML, Ribeiro ÉDP, Bittencourt S, Tunes UDR. Terapia fotodinâmica como adjuvante ao tratamento periodontal não cirúrgico. Periodontia. 2010; 20(2):22-32.
Sigusch BW, Pfitzner A, Albrecht V, Glockmann E. Efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model. J. Periodontol. 2005; 76(7):1100-5.
Karygianni L, Ruf S, Follo M, Hellwig E, Bucher M, Anderson AC, et al. Novel broad-spectrum antimicrobial photoinactivation of in situ oral biofilms by visible light plus water-filtered infrared A. Applied and environmental microbiology. 2014; 80(23):7324-36.
Prates RA, Yamada AM, Suzuki LC, Hashimoto MCE, Cai S, Gouw-Soares S, et al. Bactericidal effect of malachite green and red laser on Actinobacillus actinomycetemcomitans. J Photochem Photobiol B. 2007; 86(1):70-6.
Chan Y, Lai CH. Bactericidal effects of different laser wavelengths on periodontopathic germs in photodynamic therapy. Lasers Med Sci. 2003; 18(1):51-5.
Usacheva MN, Teichert MC, Biel MA. Comparison of the methylene blue and toluidine blue photobactericidal efficacy against gram-positive and gram-negative microorganisms. Lasers Surg Med. 2001; 29(2):165-73.
Pfitzner A, Sigusch BW, Albrecht V, Glockmann E. Killing of periodontopathogenic bacteria by photodynamic therapy. J. Periodontol. 2004; 75(10): 1343-9.
de Almeida, JM, Theodoro LH, Bosco AF, Nagata MJH, Oshiiwa M, Garcia, VG. In vivo effect of photodynamic therapy on periodontal bone loss in dental furcations.J. Periodontol. 2008; 79(6):1081-88.
Garcia VG, Gualberto Júnior EC, Fernandes LA, Bosco AF, Hitomi Nagata MJ, Casatti CA, et al. Adjunctive antimicrobial photodynamic treatment of experimentally induced periodontitis in rats with ovariectomy. J Periodontol. 2013; 84(4):556-65.
Sorkhdini P, Moslemi N, Jamshidi S, Jamali R, Amirzargar AA, Fekrazad R. Effect of Hydrosoluble Chlorine–Mediated Antimicrobial Photodynamic Therapy on Clinical Parameters and Cytokine Profile in Ligature-Induced Periodontitis in Dogs. J Periodontol. 2013; 84(6):793-800.
Theodoro LH, Silva SP, Pires JR, Soares GHG, Pontes AEF, Zuza EP, et al. Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up. Lasers Med Sci. 2012; 27(4):687-93.
Bassir SH, Moslemi N, Jamali R, Mashmouly S, Fekrazad R, Chiniforush N, et al. Photoactivated disinfection using light‐emitting diode as an adjunct in the management of chronic periodontitis: a pilot double‐blind split‐mouth randomized clinical trial. J Clin Periodonto. 2013; 40(1):65-72.
Moreira AL, Novaes Jr AB, Grisi MF, Taba Jr M, Souza SL, Palioto DB, et al. Antimicrobial photodynamic therapy as an adjunct to non-surgical treatment of aggressive periodontitis: a split-mouth randomized controlled trial. J Periodontol. 2015; 86(3):376-86.
Pourabbas R, Kashefimehr A, Rahmanpour N, Babaloo Z, Kishen A, Tenenbaum HC, et al. Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: a split-mouth randomized clinical trial. J Periodontol. 2014; 85(9):1222-9.
