Influence of particulate matter and meteorological conditions on multiple sclerosis relapse: a preliminary study in São Paulo, Brazil
DOI:
https://doi.org/10.21270/archi.v6i8.2214Resumo
Introduction: Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system, which in some cases may be characterized by recurrent relapses of inflammation that cause mild to severe neurological disability. Some studies around the world have associated the increase of systemic inflammatory responses and neuro-inflammation of patients with exposure to high levels of particulate matter (PM10) and certain conditions of temperature and humidity. Materials and methods: The objective of this study was to verify the influence of the concentration of PM10 and meteorological variables (air temperature and relative humidity) on the number of hospitalizations for MS in the city of São Paulo. Data from 2008 to 2016, which passed through descriptive statistics and inferences, were used as multiple linear regression models. Results: The models obtained indicated a positive relation (p < 0.01) in the number of hospitalizations with the increase of PM10 and relative humidity, showing that 31.23% of hospital admissions can be explained by these variables. Conclusion: These results are important, since there are no other studies from Brazil that correlate meteorological and air quality variables with MS.Descriptors: Air Pollution; Multiple Sclerosis; Linear Models.
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Baggio BF, Teles RA, Renosto A, Alvarenga FC. Peerfil epidemiológico de indivíduos com Esclerose Múltipla de uma associação de referência. Rev Neurocienc. 2011; 19(3):458-61.
Moreira MA, Felipe E, Mendes MF, Tilbery CP. Multiple sclerosis: a descriptive study of its clinical forms in 302 cases. Arq Neuro-Psychiatr. 2000; 58(2B):460-6.
Gregory AC 2nd, Shendell DG, Okosun IS, Gieseker KE. Multiple Sclerosis disease distribution and potential impact of environmental air pollutants in Georgia. Sci Total Environ. 2008, 396(1):42-51.
Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M et al.Nuclear receptor NR1H3 in familial multiple sclerosis. Neuron. 2016; 90(5):948-54.
Oliveira EML, Souza NA. Esclerose Múltipla. Rev Neurociências. 1998; 6 (3):114-8.
Finkelsztejn A. Tratamento do surto de esclerose múltipla em Hospital-Dia: estudo de custo-minimização [dissertação]. Porto Alegre: Universidade Federal do Rio Grande do Sul; 2007.
Heydarpour P, Amini H, Khoshkish S, Seidkhani H, Sahraian MA, Yunesian M. Potential Impact of Air Pollution on Multiple Sclerosis in Tehran, Iran. Neuroepidemiology. 2014; 43(3-4):233-8.
Vojinovic S, Savic D, Lukic S, Savic L, Vojinovic J. Disease relapses in multiple sclerosis can be influenced by air pollution and climate seasonal conditions. Vojnosanitetski Pregled. 2015; 72(1):44-9.
CETESB. Air quality in the state of São Paulo 2012. Environmental Commitment of the State of São Paulo, 2013.
Salvi F, Bartolomei I, Smolensky MH, Lorusso A, Barbarossa E, Malagoni AM et al. A seasonal periodicity in relapses of multiple sclerosis? A single-center, population-based, preliminary study conducted in Bologna, Italy. BMC Neurol. 2010; 10:105.
Tadano YS, Ugaya CML, Franco AT. Ressão de Poisson: metodologia para avaliação do impacto da poluição atmosférica da saúde populacional. Ambiente & Sociedade. 2009; 12(2):241-55.
Brasil. Ministério da Saúde. Portaria nº493 de 23 de setembro de 2010.
Coelho-Barros EA, Simões PA, Achcar JA, Martinez EZ, Shimano AC. Methods of estimation in multiple linear regression: application to clinical data. Rev Colomb Stad. 2008; 31(1):111-29.
Lopes MM, Castelo Branco VTF, Soares JB. Utilização dos testes estatísticos de Kolmogorov-Smirnov e Shapiro-Wilk para verificação da normalidade para materiais de pavimentação. Transportes. 2013; 21(1):59-66.
Figueiredo Filho DB, Rocha EC, Silva Junior JA, Paranhos R, Neves JAB, Silva MB. Desvendando os mistérios do coeficiente de correlação de Pearson: o retorno. Leviathan. 2014; 8:66-95.
Angelici L, Piola M, Cavalleri T, Randi G, Cortini F, Bergamaschi R, et al. Effects of particulate matter exposure on multiple sclerosis hospital admission in Lombardy region, Italy. Environ Res. 2016; 145:68-73.
Larazzi AR. Comparison of statistical techniques to analyze the relationship between respiratory diseases and concentrations of air pollutants. Ciência Natura. 2013; 35(1):98-105.
Prado FA, Berveglieri A, Tachibana VM, Imai NN. Aplicação e análise de modelos de regressão clássica e espacial para os distritos da cidade de São Paulo. In: III Simpósio Brasileiro de Ciências Geodésicas e Tecnologias da Geoinformação, 2010, Recife. Anais do III SIMGEO. Recife: Universidade Federal de Pernambuco, 2010.
Abbad G, Torres CV. Regressão múltipla stepwise e hierárquica em Psicologia Organizacional: aplicações, problemas e soluções. Estud psicol. 2002; 7(spe):19-29.
Ferreira MLB, Machado MIM, Vilela ML, Guedes MJ, Ataíde Jr L, Santos S et al. Epidemiology of 118 cases of multiple sclerosis with segments of 15 years in the reference center of the hospital of the restoration of Pernambuco. Arq Neuro-Psiquiatr. 2004; 62(4):1027-32.
Botelho C, Correia AL, Silva AMC, Macedo AG, Silva COS. Fatores ambientais e hospitalizações em crianças menores de 5 anos com infecção respiratória aguda. Cad Saúde Pública. 2003;19(6):1771-80.
Brasil. Instituto Nacional de Metrologia, Estandardização e Qualidade Industrial (INMETRO). Portaria nº 346 de 3 de outubro de 2008.
Instituto de Astronomia, Geofísica e Ciências Atmosféricas. Boletim Climatológico Anual da Estação Meteorológica do IAG/USP; 2014, v.17.
Tadano YS. Análise do impacto de MP10 na saúde populacional: estudo de caso em Araucária, PR. Curitiba [dissertação]. Curitiba: Universidade Tecnológica Federal do Paraná; 2007.
Hair JF, Black WC, Babin BJ, Anderson RE, Tatham RL. Multivariate data analysis. 6th ed, Upper Saddle River, NJ: Pearson Prentice Hall; 2006.
Bernstein JA, Alexis N, Barnes C, Bernstein IL, Nel A, Peden D et al. Health effects of air pollution. J Allergy Clin Immunol. 2004; 114(5):1116-23.
Kampa M, Castanas E. Human health effects of air pollution. Environ Pollut. 2008;151(2):362-7.
Silva AR, West JJ, Zhang Y, Anenberg SC, Lamarque JF, Shindell DT et al. Global premature mortality due to anthropogenic outdoor air pollution and the contribution of past climate change. Environ Res Lett. 2013; 8:034005.
De Toledo G, Nardocci AC. Traffic related air pollution and population health: a review about São Paulo (SP), Brazil. Rev Bras Epidemiol. 2011; 14(3):445-54.
Andrade VS, Silva MO. Qualidade de vida e desempenho ocupacional de indivíduos com esclerose múltipla. Acta Fisiatr. 2015, 22(3):135-40.
Papaléo RM, Teixeira MJ, Brioschi ML. Infrared thermography to evaluate pain in a multiple sclerosis patient. Case report. Rev Dor. 2016; 17(3):232-5.
