Clinical, morphogical and immunohistochemical aspects of oral inflammatory myofibroblastic tumor: a rare case report in a pediatric patient

Autores

  • Hellen Bandeira de Pontes Santos
  • Natália Guimarães Barbosa
  • Tiago João Silva Filho
  • Lélia Maria Guedes Queiroz
  • Alberto Gurgel
  • Roseana de Almeida Freitas
  • Patrícia Teixeira de Oliveira

DOI:

https://doi.org/10.21270/archi.v7i10.3088

Resumo

Inflammatory myofibroblastic tumor (IMT) is a rare benign neoplasm composed by myofibroblasts and fibroblasts admixed with inflammatory cells. Here, we report a case of IMT in the oral cavity of left mandible of a 12-year-old boy. Histopathological investigation revealed a proliferation of fibroblasts and myofibroblasts (positive for alpha-smooth muscle actin and vimentin) associated with inflammatory cells. The patient is still under follow-up and without evidence of recurrence. Oral IMT is a challenge for the clinician in diagnosis due to the nonspecific clinical presentation. Thus, histology and immunohistochemistry are required to reach an accurate diagnosis of this lesion.

Descriptors: Neoplasms; Diagnosis; Immunohistochemistry.

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Referências

Korlepara R, Guttikonda VR, Madala J, Taneeru S. Inflammatory myofibroblastic tumor of mandible: A rare case report and review of literature. J Oral Maxillofac Pathol. 2017; 21(1):136-39.

Tateishi Y, Okudela K, Kawai S, Suzuki T, Umeda S, Matsumara M et al. Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: a case report. Diagn Pathol. 2016; 11(1):132.

Binmadi NO, Packman H, Papadimitriou JC, Scheper M. Oral inflammatory myofibroblastic tumor: case report and review of literature. Open Dent J. 2011; 5:66-70.

Liston SL, Dehner LP, Jarvis CW, Pitzele C, Huseby TL. Inflammatory pseudotumors in the buccal tissues of children. Oral Surg Oral Med Oral Pathol. 1981; 51(3):287-91.

Coffin CM, Humphrey PA, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Semin Diagn Pathol. 1998; 15(2):85-101.

Xavier FC, Rocha AC, Sugaya NN, dos Santos-Pinto D Jr, de Sousa SC. Fibronectin as an adjuvant in the diagnosis of oral inflammatory myofibroblastic tumor. Med Oral Patol Oral Cir Bucal. 2009; 14(12):e635-39.

Stringer DE, Allen CN, Nguyen K, Tandon R. Intraosseous inflammatory myofibroblastic tumor in the mandible: a rare pathologic case report. Case Rep Surg. 2014; 2014: 565478.

Guilemany JM, Alós L, Alobid I, Bernal-Sprekelsen M, Cardesa A. Inflammatory myofibroblastic tumor in the larynx: clinicopathologic features and histogenesis. Acta Otolaryngol. 2005; 125(2):215-19.

Lizarbe MO, Olascoaga JH, García ER, Castiella TM, Sagaseta de Ilúrdoz Uranga María M, Garicano JM. Paediatric myofibroblastic tumours. A presentation of three cases. An Pediatr (Barc). 2009; 71(4):331-35.

Ide F, Shimoyama T, Horie N. Inflammatory pseudotumor in the mandibular retromolar region. J Oral Pathol Med. 1998; 27(10):508-10.

Jordan RC, Regezi JA. Oral spindle cell neoplasms: a review of 307 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95(6):717-24.

Fang JC, Dym H. Myofibroblastic tumor of the oral cavity. A rare clinical entity. NY State Dent J. 2004; 70(3):28-30.

Brooks JK, Nikitakis NG, Frankel BF, Papadimitriou JC, Sauk JJ. Oral inflammatory myofibroblastic tumor demonstrating ALK, p53, MDM2, CDK4, pRb, and Ki-67 immunoreactivity in an elderly patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99(6):716-26.

Poh CF, Priddy RW, Dahlman DM. Intramandibular inflammatory myofibroblastic tumor-a true neoplasm or reactive lesion? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 100(4):460-66.

Johann AC, Caldeira PC, Abdo EN, Sousa SO, Aguiar MC, Mesquita RA. Inflammatory myofibroblastic tumor of the alveolar mucosa of the mandible. Minerva Stomatol. 2008; 57(1-2):59-63.

Oh JH, Yim JH, Yoon BW, Choi BJ, Lee DW, Kwon YD. Inflammatory pseudotumor in the mandible. J Craniofac Surg. 2008; 19(6):1552-53.

Palaskar S, Koshti S, Maralingannavar M, Bartake A. Inflammatory myofibroblastic tumor. Contemp Clin Dent. 2011; 2(4):274-77.

Kim SY, Yang SE. Inflammatory myofibroblastic tumor of the maxillary sinus related with pulp necrosis of maxillary teeth: case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 112(5):684-87.

Lourenço SV, Boggio P, Simonsen Nico MM. Inflammatory myofibroblastic tumor of the tongue: report of an unusual case in a teenage patient. Dermatol Online J. 2012; 18(5):6.

Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995; 19(8):859-72.

Meis JM, Enzinger FM. Inflammatory fibrosarcoma of the mesentery and retroperitoneum. A tumor closely simulating inflammatory pseudotumor. Am J Surg Pathol. 1991; 15(12):1146-56.

Goldblum JR, Weiss SW, Folpe AL. Enzinger and Weiss's soft tissue tumors. 6th ed. Philadelphia, PA: Saunders/Elsevier; 2014.

Swain RS, Tihan T, Horvai AE, Di Vizio D, Loda M, Burger PC et al. Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor. Hum Pathol. 2008; 39(3):410-19.

Ong HS, Ji T, Zhang CP, Li J, Wang LZ, Li RR. Head and neck inflammatory myofibroblastic tumor (IMT): evaluation of clinicopathologic and prognostic features. Oral Oncol. 2012; 48(2):141-48.

Cessna MH, Zhou H, Sanger WG, Perkins SL, Tripp S, Pickering D et al. Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol. 2002; 15(9):931-38.

Pankaj C, Uma C. How to manage oral inflammatory myofibroblastic tumor (inflammatory pseudotumor)? Oral Dis. 2001; 7(5):315-16.

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Publicado

2018-12-13

Como Citar

Santos, H. B. de P., Barbosa, N. G., Silva Filho, T. J., Queiroz, L. M. G., Gurgel, A., Freitas, R. de A., & Oliveira, P. T. de. (2018). Clinical, morphogical and immunohistochemical aspects of oral inflammatory myofibroblastic tumor: a rare case report in a pediatric patient. ARCHIVES OF HEALTH INVESTIGATION, 7(10). https://doi.org/10.21270/archi.v7i10.3088

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