Síndrome de Gorlin-Goltz: características sistêmicas e maxilofaciais

  • Jefferson David Melo de Matos
  • Leonardo Jiro Nomura Nakano
  • Pedro Jacy Santos Diamantino
  • Guilherme da Rocha Scalzer Lopes
  • Marco Antonio Bottino
  • John Eversong Lucena de Vasconcelos
  • Nathália de Carvalho Ramos
  • Valdir Cabral Andrade
Palavras-chave: Síndrome do Nevo Basocelular, Patologia Bucal, Odontologia

Resumo

Gorlin-Goltz Syndrome, also known as Nevoid Basal Cell Carcinoma Syndrome, is a rare genetic disorder characterized by the presence of multiple keratocysts in the jaw and basal cell carcinomas, at young age, of palmar and/or plantar depressions, of calcification of the sickle cerebral and skeletal malformations. This syndrome is caused by a mutation of the PTCH1 (patched homolog 1 from Drosophila) gene, a tumor suppressor gene. In this work, the systemic and maxillofacial characteristics of the Gorlin-Goltz syndrome, as well as some neurological, dermatological, musculoskeletal and endocrine alterations, are reviewed. In addition, a case report was added for the purpose of support this study.

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Publicado
2020-10-22
Como Citar
Matos, J. D. M. de ., Nakano, L. J. N., Diamantino, P. J. S., Lopes, G. da R. S., Bottino, M. A., Vasconcelos, J. E. L. de ., Ramos, N. de C., & Andrade, V. C. (2020). Síndrome de Gorlin-Goltz: características sistêmicas e maxilofaciais. ARCHIVES OF HEALTH INVESTIGATION, 10(1), 49-54. https://doi.org/10.21270/archi.v10i1.4853
Seção
Original Articles