Terapia fotodinâmica antimicrobiana como recurso adjuvante no tratamento endodôntico em dentes infectados: análise bibliométrica e revisão de literatura
DOI:
https://doi.org/10.21270/archi.v10i1.5013Palavras-chave:
Endodontia, Tratamento do Canal Radicular, Desinfecção, Terapia a Laser, FotoquimioterapiaResumo
As infecções endodônticas são caracterizadas por apresentarem uma microbiota diversificada e complexa, desempenhando um papel importante no desenvolvimento das patologias pulpares e periapicais. Entretanto, apesar de o controle dessa infecção ser o principal objetivo do tratamento endodôntico de dentes infectados, os procedimentos químico-mecânicos podem falhar na remoção dos microrganismos patogênicos no sistema de canais radiculares, sendo necessário a realização de estratégias adjuvantes para sua desinfecção. Dentre essas, a terapia fotodinâmica antimicrobiana tem se destacado como um método promissor no tratamento das infecções endodônticas. Diante disso, este estudo consiste em uma análise bibliométrica e uma revisão de literatura acerca do uso da laserterapia através da terapia fotodinâmica como estratégia adjuvante na desinfecção dos canais radiculares. O levantamento de dados deste trabalho foi realizado nas bases de dados PUBMED, Science Direct e Scielo, incluindo-se um total de 39 artigos. Assim, foram detalhados e discutidos aspectos gerais acerca das limitações encontradas nos procedimentos químico-mecânicos convencionais durante o tratamento endodôntico, destacando nesse contexto aspectos como a importância, as vantagens, o mecanismo e a eficácia da utilização da terapia fotodinâmica como recurso adjuvante no tratamento endodôntico de dentes infectados, concluindo-se que a utilização da terapia fotodinâmica representa uma estratégia promissora e eficaz para ser utilizada em associação com os protocolos de desbridamento químico-mecânico convencional visando à potencialização da desinfecção dos canais radiculares.
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Referências
Pourhajibagher M, Chiniforush N, Raoofian R, Pourakbari B, Ghorbanzadeh R, Bazarjani F et al.. Evaluation of photo-activated disinfection effectiveness with methylene blue against Porphyromonas gingivalis involved in endodontic infection: An in vitro study. Photodiagnosis Photodyn Ther. 2016;16:132-35.
Pourhajibagher M, Ghorbanzadeh R, Parker S, Chiniforush N, Bahador A. The evaluation of cultivable microbiota profile in patients with secondary endodontic infection before and after photo-activated disinfection. Photodiagnosis Photodyn Ther. 2017;18:198-203.
Sarda RA, Shetty RM, Tamrakar A, Shetty SY. Antimicrobial efficacy of photodynamic therapy, diode laser, and sodium hypochlorite and their combinations on endodontic pathogens. Photodiagnosis Photodyn Ther. 2019;28:265-72.
Pourhajibagher M, Plotino G, Chiniforush N, Bahador A. Dual wavelength irradiation antimicrobial photodynamic therapy using indocyanine green and metformin doped with nano-curcumin as an efficient adjunctive endodontic treatment modality. Photodiagnosis Photodyn Ther. 2020;29:101628.
Bolhari B, Pourhajibagher M, Bazarjani F, Chiniforush N, Rad MR, Pirmoazen S et al.. Ex vivo assessment of synergic effect of chlorhexidine for enhancing antimicrobial photodynamic therapy efficiency on expression patterns of biofilm-associated genes of Enterococcus faecalis. Photodiagnosis Photodyn Ther. 2018;22:227-32.
Pourhajibagher M, Raoofian R, Ghorbanzadeh R, Bahador A. An experimental study for rapid detection and quantification of endodontic microbiota following photo-activated disinfection via new multiplex real-time PCR assay. Photodiagnosis Photodyn Ther. 2018;21:344-350.
Asnaashari M, Godiny M, Azari-Marhabi S, Tabatabaei FS, Barati M. Comparison of the Antibacterial Effect of 810 nm Diode Laser and Photodynamic Therapy in Reducing the Microbial Flora of Root Canal in Endodontic Retreatment in Patients With Periradicular Lesions. J Lasers Med Sci. 2016;7(2):99-104.
Bordea IR, Hanna R, Chiniforush N, Grădinaru E, Câmpian RS, Sîrbu A, Amaroli A, Benedicenti S. Evaluation of the outcome of various laser therapy applications in root canal disinfection: A systematic review. Photodiagnosis Photodyn Ther. 2020; 29:101611.
Armand A, Khani M, Asnaashari M, AliAhmadi A, Shokri B. Comparison study of root canal disinfection by cold plasma jet and photodynamic therapy. Photodiagnosis Photodyn Ther. 2019;26:327-333.
Akbari T, Pourhajibagher M, Hosseini F, Chiniforush N, Gholibegloo E, Khoobi M et al. The effect of indocyanine green loaded on a novel nano-graphene oxide for high performance of photodynamic therapy against Enterococcus faecalis. Photodiagnosis Photodyn Ther. 2017;20:148-153.
Beltes C, Sakkas H, Economides N, Papadopoulou C. Antimicrobial photodynamic therapy using Indocyanine green and near-infrared diode laser in reducing Entrerococcus faecalis. Photodiagnosis Photodyn Ther. 2017;17:5-8.
Ghorbanzadeh A, Fekrazad R, Bahador A, Ayar R, Tabatabai S, Asefi S. Evaluation of the antibacterial efficacy of various root canal disinfection methods against Enterococcus faecalis biofilm. An ex-vivo study. Photodiagnosis Photodyn Ther. 2018;24:44-51.
Pourhajibagher M, Bahador A. Adjunctive antimicrobial photodynamic therapy to conventional chemo-mechanical debridement of infected root canal systems: A systematic review and meta-analysis. Photodiagnosis Photodyn Ther. 2019;26:19-26.
Ghorbanzadeh A, Bahador A, Sarraf P, Ayar R, Fekrazad R, Asefi S. Ex vivo comparison of antibacterial efficacy of conventional chemomechanical debridement alone and in combination with light-activated disinfection and laser irradiation against Enterococcus faecalis biofilm. Photodiagnosis Photodyn Ther. 2020;29:101648.
Batinić M, Ročan M, Budimir A, Anić I, Bago I. Comparison of final disinfection protocols using antimicrobial photodynamic therapy and different irrigants after single-file reciprocating instrumentation against intracanal bacterial biofilm - An in vitro study. Photodiagnosis Photodyn Ther. 2018;24:153-57.
Rosa RAD, Santini MF, Figueiredo JAP, Visioli F, Pereira JR, Vivan RR, Montagner F, Só MVR. Effectiveness of photodynamic therapy associated with irrigants over two biofilm models. Photodiagnosis Photodyn Ther. 2017;20:169-74.
Mohammadi Z, Jafarzadeh H, Shalavi S, Palazzi F. Recent Advances in Root Canal Disinfection: A Review. Iran Endod J. 2017;12(4):402-6.
Mohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita JI. Photodvnamic Therapy in Endodontics. J Contemp Dent Pract. 2017;18(6):534-38.
Soares JA, Soares SMCS, de Jesus Tavarez RR, de Castro Rizzi C, Vaz Rodrigues SCG, Maia Filho EM et al. Exploring different photodynamic therapy parameters to optimize elimination of Enterococcus faecalis in planktonic form. Photodiagnosis Photodyn Ther. 2018;22:127-131.
Moradi Eslami L, Vatanpour M, Aminzadeh N, Mehrvarzfar P, Taheri S. The comparison of intracanal medicaments, diode laser and photodynamic therapy on removing the biofilm of Enterococcus faecalis and Candida albicans in the root canal system (ex-vivo study). Photodiagnosis Photodyn Ther. 2019;26:157-61.
Pourhajibagher M, Kazemian H, Chiniforush N, Hosseini N, Pourakbari B, Azizollahi A et al. Exploring different photosensitizers to optimize elimination of planktonic and biofilm forms of Enterococcus faecalis from infected root canal during antimicrobial photodynamic therapy. Photodiagnosis Photodyn Ther. 2018;24:206-11.
Chiniforush N, Pourhajibagher M, Parker S, Shahabi S, Bahador A. The in vitro effect of antimicrobial photodynamic therapy with indocyanine green on Enterococcus faecalis: Influence of a washing vs non-washing procedure. Photodiagnosis Photodyn Ther. 2016;16:119-23.
Rabello DGD, Corazza BJM, Ferreira LL, Santamaria MP, Gomes APM, Martinho FC. Does supplemental photodynamic therapy optimize the disinfection of bacteria and endotoxins in one-visit and two-visit root canal therapy? A randomized clinical trial. Photodiagnosis Photodyn Ther. 2017;19:205-11.
Plotino G, Grande NM, Mercade M. Photodynamic therapy in endodontics. Int Endod J. 2019;52(6):760-74.
Afkhami F, Akbari S, Chiniforush N. Entrococcus faecalis Elimination in Root Canals Using Silver Nanoparticles, Photodynamic Therapy, Diode Laser, or Laser-activated Nanoparticles: An In Vitro Study. J Endod. 2017;43(2):279-82.
Mohan D, Maruthingal S, Indira R, Divakar DD, Al Kheraif AA, Ramakrishnaiah R et al. Photoactivated disinfection (PAD) of dental root canal system - An ex-vivo study. Saudi J Biol Sci. 2016;23(1):122-27.
Pourhajibagher M, Chiniforush N, Raoofian R, Ghorbanzadeh R, Shahabi S, Bahador A. Effects of sub-lethal doses of photo-activated disinfection against Porphyromonas gingivalis for pharmaceutical treatment of periodontal-endodontic lesions. Photodiagnosis Photodyn Ther. 2016;16:50-53.
Soares JA, Santos Soares SMC, Santos César CA, de Carvalho MAR, Brito-Júnior M, de Sousa GR, Soares BM, de Macêdo Farias L. Monitoring the effectiveness of photodynamic therapy with periodic renewal of the photosensitizer on intracanal Enterococcus faecalis biofilms. Photodiagnosis Photodyn Ther. 2016;13:123-27.
Susila AV, Sugumar R, Chandana CS, Subbarao CV. Combined effects of photodynamic therapy and irrigants in disinfection of root canals. J Biophotonics. 2016;9(6):603-9.
Garcez AS, Hamblin MR. Methylene Blue and Hydrogen Peroxide for Photodynamic Inactivation in Root Canal - A New Protocol for Use in Endodontics. Eur Endod J. 2017;2(1):1-7.
Pourhajibagher M, Chiniforush N, Ghorbanzadeh R, Bahador A. Photo-activated disinfection based on indocyanine green against cell viability and biofilm formation of Porphyromonas gingivalis. Photodiagnosis Photodyn Ther. 2017;17:61-4.
Prażmo EJ, Godlewska RA, Mielczarek AB. Effectiveness of repeated photodynamic therapy in the elimination of intracanal Enterococcus faecalis biofilm: an in vitro study. Lasers Med Sci. 2017;32(3):655-61.
Souza MA, Lima G, Pazinatto B, Bischoff KF, Palhano HS, Cecchin D. Evaluation of antimicrobial activity of association of chlorhexidine to photosensitizer used in photodynamic therapy in root canals infected by Enterococcus faecalis. Photodiagnosis Photodyn Ther. 2017;19:170-74.
Chiniforush N, Pourhajibagher M, Parker S, Benedicenti S, Shahabi S, Bahador A. The effect of sublethal photodynamic therapy on the expression of Enterococcal surface protein (esp) encoding gene in Enterococcus faecalis: Quantitative real-time PCR assessment. Photodiagnosis Photodyn Ther. 2018;24:311-17.
Golmohamadpour A, Bahramian B, Khoobi M, Pourhajibagher M, Barikani HR, Bahador A. Antimicrobial photodynamic therapy assessment of three indocyanine green-loaded metal-organic frameworks against Enterococcus faecalis. Photodiagnosis Photodyn Ther. 2018;23:331-38.
Pourhajibagher M, Bahador A. An in vivo evaluation of microbial diversity before and after the photo-activated disinfection in primary endodontic infections: Traditional phenotypic and molecular approaches. Photodiagnosis Photodyn Ther. 2018;22:19-25.
Pourhajibagher M, Bahador A. Diagnostic accuracy of multiplex real-time PCR approaches compared with cultivation -based detection methods: Monitoring the endopathogenic microbiota pre and post photo-activated disinfection. Photodiagnosis Photodyn Ther. 2018;22:140-46.
Katalinić I, Budimir A, Bošnjak Z, Jakovljević S, Anić I. The photo-activated and photo-thermal effect of the 445/970 nm diode laser on the mixed biofilm inside root canals of human teeth in vitro: A pilot study. Photodiagnosis Photodyn Ther. 2019;26:277-83.
Pourhajibagher M, Chiniforush N, Bahador A. Antimicrobial action of photoactivated C-Phycocyanin against Enterococcus faecalis biofilms: Attenuation of quorum-sensing system. Photodiagnosis Photodyn Ther. 2019;28:286-91.
