Níveis Reduzidos de Melatonina Salivar em Indivíduos com Doença Periodontal: Revisão Sistematizada
DOI:
https://doi.org/10.21270/archi.v11i2.5280Palavras-chave:
Doenças Periodontais, Melatonina, BocaResumo
Objetivo: Esta revisão da literatura visa identificar e sumarizar estudos que avaliaram os níveis de melatonina salivar em indivíduos com doença periodontal (DP). Metodologia: Realizou-se busca sistemática de publicações científicas nas seguintes bases de dados: PubMed, SCOPUS, LILACS, EMBASE, BIREME e SciELO, utilizando os termos “Doença periodontal”, “Melatonina” e “Saliva” em português e inglês. Resultados: Houve predomínio de estudos do tipo caso controle; os artigos apresentaram níveis de evidência e graus de recomendação moderada que evidenciaram diminuição dos níveis de melatonina salivar nos sujeitos com DP comparados aos controles. Conclusões: As evidências cientificas apontam que os níveis de melatonina salivar estão diminuídos na doença periodontal.
Downloads
Referências
Williams RC. Periodontal disease. N Engl J Med. 1990;322(6):373-82.
Di Benedetto A, Gigante I, Colucci S, Grano M. Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol. 2013;2013:503754.
Socransky SS, Haffajee AD, Ximenez-Fyvie LA, Feres M, Mager D. Ecological considerations in the treatment of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis periodontal infections. Periodontol 2000. 1999;20:341-62.
Araslan S, Alencar COd, Cortelli JR, Cortelli SC, Aquino DR. Presence of Aggregatibacter actinomycetemcomitans in association with Porphyromonas gingivalis and Prevotella intermedia in periodontal patients. IJD, Int j dent. 2010;9(4):187-92.
Morrison DC, Ryan JL. Endotoxins and disease mechanisms. Annu Rev Med. 1987;38:417-32.
Hernandez M, Dutzan N, Garcia-Sesnich J, Abusleme L, Dezerega A, Silva N, et al. Host-pathogen interactions in progressive chronic periodontitis. J Dent Res. 2011;90(10):1164-70.
Ali J, Pramod K, Tahir MA, Ansari SH. Autoimmune responses in periodontal diseases. Autoimmun Rev. 2011;10(7):426-31.
Lalla E, Lamster IB, Schmidt AM. Enhanced interaction of advanced glycation end products with their cellular receptor RAGE: implications for the pathogenesis of accelerated periodontal disease in diabetes. Ann Periodontol. 1998;3(1):13-9.
Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, et al. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105(8):1117-24.
Taubman MA, Valverde P, Han X, Kawai T. Immune response: the key to bone resorption in periodontal disease. J Periodontol. 2005;76(11 Suppl):2033-41.
Kumar KR, Ranganath V, Naik R, Banu S, Nichani AS. Assessment of high-sensitivity C-reactive protein and lipid levels in healthy adults and patients with coronary artery disease, with and without periodontitis--a cross-sectional study. J Periodontal Res. 2014;49(6):836-44.
Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005; 366(9499):1809-20.
Egermann M, Gerhardt C, Barth A, Maestroni GJ, Schneider E, Alini M. Pinealectomy affects bone mineral density and structure--an experimental study in sheep. BMC Musculoskelet Disord. 2011;12:271.
Amstrup AK, Sikjaer T, Mosekilde L, Rejnmark L. Melatonin and the skeleton. Osteoporos Int. 2013;24(12):2919-27.
Maria S, Witt-Enderby PA. Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures. J Pineal Res. 2014;56(2):115-25.
Cipolla-Neto J, Afeche SC. Glândula Pineal. In: Aires MM. (Ed.). Fisiologia. 3 ed. Rio de Janeiro; 2008.
Pandi-Perumal SR, Srinivasan V, Maestroni GJ, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: Nature's most versatile biological signal? Febs j. 2006;273(13):2813-38.
Folkard S. Do permanent night workers show circadian adjustment? A review based on the endogenous melatonin rhythm. Chronobiol Int. 2008;25(2):215-24.
Reiter RJ, Tan DX, Manchester LC, Paredes SD, Mayo JC, Sainz RM. Melatonin and reproduction revisited. Biol Reprod. 2009; 81(3):445-56.
Sanchez-Barcelo EJ, Mediavilla MD, Tan DX, Reiter RJ. Scientific basis for the potential use of melatonin in bone diseases: osteoporosis and adolescent idiopathic scoliosis. J Osteoporos. 2010;2010:830231.
Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51(1):1-16.
Cengiz M, Cengiz S, Wang HL. Melatonin and Oral Cavity. Int J Dent. 2012;2012
Mayo JC, Sainz RM, Tan DX, Hardeland R, Leon J, Rodriguez C, et al. Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. J Neuroimmunol. 2005;165(1-2):139-49.
Cutando A, Gomez-Moreno G, Arana C, Acuna-Castroviejo D, Reiter RJ. Melatonin: potential functions in the oral cavity. J Periodontol. 2007;78(6):1094-102.
Laakso ML, Porkka-Heiskanen T, Alila A, Stenberg D, Johansson G. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J Pineal Res. 1990;9(1):39-50.
Bob Phillips CB, Dave Sackett, Doug Badenoch, Sharon Straus, Brian Haynes, Martin Dawes since. Oxford Centre for Evidence-based Medicine: levels of evidence March, 2009.
Srinath R, Acharya AB, Thakur SL. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J Periodontol. 2010;81(2):277-83.
Acuna-Castroviejo D, Escames G, Venegas C, Diaz-Casado ME, Lima-Cabello E, Lopez LC, et al. Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci. 2014;71(16):2997-3025.
Pinato L, da Silveira Cruz-Machado S, Franco DG, Campos LMG, Cecon E, Fernandes P, et al. Selective protection of the cerebellum against intracerebroventricular LPS is mediated by local melatonin synthesis. Brain Struct Funct. 2015;220(2):827-40.
Reiter RJ, Tan DX. What constitutes a physiological concentration of melatonin? J Pineal Res. 2003;34(1):79-80.
Markus RP, Cecon E, Pires-Lapa MA. Immune-pineal axis: nuclear factor kappaB (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells. Int J Mol Sci. 2013;14(6):10979-97.
Gomez-Moreno G, Cutando-Soriano A, Arana C, Galindo P, Bolanos J, Acuna-Castroviejo D, et al. Melatonin expression in periodontal disease. J Periodontal Res. 2007;42(6):536-40.
Zaminy A, Kashani IR, Barbarestani M, Hedayatpour A, Mahmoudi R, Vardasbi S et al. Effects of melatonin on the proliferation and differentiation of rat adipose-derived stem cells. Indian J Plast Surg.2008;41(1):8-14
Ikegami M, Hattori A, Tabata MJ, Kitamura KI, Tabuchi Y, Furusawa Y et al. Melatonin is a potential drug for the prevention of bone loss during space flight. Journal of pineal research. 2019;67(3):e12594.
Kumasaka S, Shimozuma M, Kawamoto T, Mishima K, Tokuyama R, Kamiya Y et al. Possible involvement of melatonin in tooth development: expression of melatonin 1a receptor in human and mouse tooth germs. Histochem Cell Biol. 2010;133(5):577-84.
Almughrabi OM, Marzouk KM, Hasanato RM, Shafik SS. Melatonin levels in periodontal health and disease. J Periodontal Res. 2013;48(3):315-21.
Bertl K, Schoiber A, Haririan H, Laky M, Steiner I, Rausch WD, et al. Non-surgical periodontal therapy influences salivary melatonin levels. Clin Oral Investig. 2013;17(4):1219-25.
Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med. 1999;10(4):458-76.
Pontes GN, Cardoso EC, Carneiro-Sampaio MM, Markus RP. Pineal melatonin and the innate immune response: the TNF-alpha increase after cesarean section suppresses nocturnal melatonin production. J Pineal Res. 2007;43(4):365-71.
da Silveira Cruz-Machado S, Pinato L, Tamura EK, Carvalho-Sousa CE, Markus RP. Glia-pinealocyte network: the paracrine modulation of melatonin synthesis by tumor necrosis factor (TNF). PLoS One. 2012;7(7):e40142.
Sack RL, Lewy AJ, Erb DL, Vollmer WM, Singer CM. Human melatonin production decreases with age. J Pineal Res. 1986;3(4):379-88.
Bescos R, Boden MJ, Jackson ML, Trewin AJ, Marin EC, Levinger I, et al. Four days of simulated shift work reduces insulin sensitivity in humans. Acta physiologica (Oxford, England). 2018
Bonmati-Carrion MA, Arguelles-Prieto R, Martinez-Madrid MJ, Reiter R, Hardeland R, Rol MA, et al. Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure International J Mol Sci. 2014;15(12): 23448-500.
Mendes SS, Martino MMFD. Shift work: overall health state related to sleep in nursing workers. Rev esc enferm USP. 2012;46(6):1471-76.
Ishizuka Y, Yoshino K, Takayanagi A, Sugihara N, Maki Y, Kamijyo H. Comparison of the oral health problems and behavior of male daytime-only and night-shift office workers: An Internet survey. J Occup Health. 2016;58(2):155-62.
Han DH, Khang YH, Jung-Choi K, Lim S. Association between shift work and periodontal health in a representative sample of an Asian population. Scand J Work Environ Health. 2013;39(6):559-67.
