Efeitos da Combinação da Bebida Fermentada de Kefir com Extrato Hidroetanólico de Guaraná (Paullinia cupana) sobre os Parâmetros Bioquímicos e Histologia de Ratos Diabéticos
DOI:
https://doi.org/10.21270/archi.v11i2.5565Palavras-chave:
Diabetes mellitus, Kefir, Paullinia cupanaResumo
A associação do Kefir e o guaraná, ambos reconhecidos pelos seus efeitos convenientes para saúde poderiam resultar em propriedades benéficas para o tratamento da diabetes mellitus (DM). O objetivo desse trabalho foi avaliar os efeitos do Kefir de água e do extrato hidroetanólico de guaraná (Paullinia Cupana), utilizados individualmente ou associados, em melhorar os parâmetros bioquímicos e histologia de ratos diabéticos. Os animais foram divididos em 5 grupos experimentais. Grupo 1: ratos sem DM; grupo 2: ratos com DM; grupo 3: ratos com DM tratados com Kefir de água; grupo 4: ratos com DM tratados com extrato hidroetanólico de guaraná; grupo 5: ratos com DM tratados com Kefir de água e extrato hidroetanólico de guaraná. Após o tratamento foram avaliados os efeitos dessas formulações na glicemia de jejum, colesterol, triglicerídeos, creatinina e as enzimas alanina aminotransferase (ALT) e aspartato aminotransferase (AST). As dietas com Kefir, Guaraná e a combinação preveniram a hiperglicemia em ratos diabéticos (p <0,05) em comparação aos animais do grupo controle/diabético. O tratamento com Guaraná e Kefir com guaraná preveniu o aumento dos níveis séricos de AST, e tanto o tratamento com Kefir, guaraná ou a combinação deles preveniu o aumento de ALT, tendo maior significância nos dois últimos grupos. Além disso, os grupos tratados com Kefir e com guaraná apresentaram uma melhora nos níveis de creatinina. Conclui-se que as dietas apresentaram potencial para prevenir algumas complicações do DM, justificando melhores investigações.
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