Osseointegração de Implantes Instalados sem Estabilidade Primária: o Papel dos Materiais à Base de Fibrina e Fosfato de Cálcio
Resumo
Quando implantes são instalados imediatamente após a extração dentária pode ocorrer ancoragem primária diminuída, atraso ou deficiência do processo de osseointegração. Isto se dá em razão da ampla interface entre as paredes circundantes do alvéolo e a superfície do implante. Para reconstrução, substituição ou preenchimento de defeitos ósseos a solução pode ser obtida com a utilização de enxertos ósseos de origem autógena, homógena ou heterógena. Frente às limitações têm-se intensificado as pesquisas para o desenvolvimento de materiais aloplásticos que apresentem características adequadas de biocompatibilidade e osseointegração. O propósito deste trabalho é discutir a aplicação de materiais à base de fibrina e fosfato de cálcio, comumente usados.Palavras chave: Implantes dentários, Osseointegração, Fibrina, Fosfato de cálcio.
Downloads
Referências
Alves-Rezende MCR, Carvalho LMF, Louzada MJQ, Escada ALA, Capelatto P, Grandini CR, Alves-Claro APR. Análise morfológica de implantes do sistema Ti-Ta. Influência do ácido tranexâmico. UNOPAR Cient Ciênc Biol Saúde 2012;14(Esp):39
Lioubavina-Hack N, Lang NP, Karring T. Signicance of primary stability for osseointegration of dental implants. Clin Oral Implants Res 2006; 17(3): 244-50
Souza FA. Aplicação do copolímero pla/pga adicionado ao fosfato de cálcio ao redor de implantes osseointegráveis instalados sem estabilidade primária em tíbia de coelhos: estudo biomecânico, histométrico e imunoistoquímico. 2006. 66f. [dissertação] Faculdade de Odontologia, Universidade Estadual Paulista, Araçatuba, SP.
Alves-Rezende MCR, Bonfietti LH, Escada ALA, Kimaid MIE, Alves-Claro APR. Implant surface modification by biomimetic-coating. Histomorphometric rat study
J Dent Res 91 (Spec Iss B), 516
Capalbo BC; Alves-Rezende MCR; Louzada MJQ; Alves-Claro APR. Geração do coágulo sanguíneo, formação óssea e osseointegração de implantes dentários: ação do ácido tranexâmico. Arch Health Invest 2012; 1(Spec):38.
Alves-Rezende MCR, Dekon SFC, Grandini CR, Bertoz APM, Alves-Claro APR. Tratamento de superfície de implantes dentários: SBF. Rev Odontol Araçatuba 2011; 32:38-43.
Bauer TW, Muschler GF. Bone graft materials: an overview of the basic science. Clin Orthopaed Rel Res 2000; 371: 10-27.
Burstein FD, Cohen SR, Hudgins R, Boydston W, Simms C. The use of hydroxyapatite cement in secondary craniofacial reconstruction. Plast Reconstr Surg. 1999 ;104:1270-5.
Huang W, Carlsen B, Wulur I, Rudkin G, Ishida K, Wu B, et al. BMP-2 exerts differential effects on differentiation of rabbit bone marrow stromal cells grown in two-dimensional and three-dimensional systems and is required for in vitro bone formation in a PLGA scaffold. Exp Cell Res 2004: 299:325-34.
Ivanoff CJ, Sennerby L, Lekholm U. Influence of mono and bicortical anchorage on the integration of titanium implants. A study in the rabbit tibia. Int J Oral Maxillofac Surg 1996; 25 (3): 229-35.
Lorenzoni M, Pertl C, Keil C, Wegscheider WA. Treatment of peri-implant defects with guided bone regeneration: a comparative clinical study with various membranes and bone grafts. Int J Oral Maxillofac Implants 1998; 13 (5): 639-46.
Shirane HY, Oda DY, Pinheiro TC, Cunha MR. Implante de biomateriais em falha óssea produzida em fíbula de ratos. Rev Bras Ortop 2010; 45(5):478-82
Feng B, Weng J, Yang BC, Qu SX, Zhang XD. Characterization of surface oxide films on titanium and adhesion of osteoblast. Biomaterials 2003; 24: 4663:70.
Marini E, Valdinucci F, Silvestrini G, Moretti S, Carlesimo M, Poggio C, et al. Morphological investigations on bone formation in hydroxyapatite-fibrin implants in human maxillary and mandibular bone. Cells Mater 2004; 4: 231-46.
Alves-Rezende MCR, Kusuda R, Grisoto LC, Alves LMN, Felipini RC, Okamoto R, Okamoto T, Alves-Rezende LGR, Garcia da Silva TC, Túrcio KHL, Alves Claro APR. Uso de benzodiazepínicos no pré-operatório. Efeito sobre o reparo ósseo. Rev Odontol Araçatuba 2009; 30 (2): 14-18.
Turunen T, Peltola J, Helenius H, Yli-Urpo A, Happonen RP. Bioactive glass and calcium carbonate granules as filler material around titanium and bioactive glass implants in the medullar space of the rabbit tibia. Clin Oral Implants Res 1997; 8:96-102.
Lu HH, Kofron MD, El-amin SF, Attawia MA, Laurencin CT. In vitro bone formation using muscle-derived cells: a new paradigm for bone tissue engineering using polymer–bone morphogenetic protein matrices. Biochem Biophys Res Commun 2003; 305(4):882-9
Fox K, Tran PA, Tran N. Recent Advances in Research Applications of Nanophase Hydroxyapatite. Chem Phys Chem 2012; 13: 2495 – 2506.
Monroe Z, Votawa W, Bass D, McMullen J. New calcium phosphate ceramic material for bone and tooth implants J Dent Res 1971; 50(4):860-1.
Moreira ASB, Pastoreli MT, Damasceno LHF, Defino HLA. Estudo experimental da influência das dimensões dos grânulos de hidroxiapatita na integração óssea. Acta Ortop Bras 2003; 11(4) :240-50.
Wagner W, Wiltfang J, Pistner H, Yildirim M, Ploder B, Chapman M, et al. Bone formation with a biphasic calcium phosphate combined with fibrin sealant in maxillary sinus floor elevation for delayed dental implant. Clin. Oral Impl Res 2012; 23:1112–7
Abiraman S, Varma HK, Umashankar PR, John A. Fibrin glue as an osteoinductive protein in a mouse model. Biomaterials. 2002; 23:3023-31.
Alves-Rezende MCR, Okamoto T. Effects of fibrin adhesive material (Tissucol) on alveolar healing in rats under stress. Braz Dent J 1997; 8(1):13-9.
Corsetti AM, Leite MGT, Ponzoni D, Puricelli E. Avaliação da presença de microrgranismos aeróbios em blocos de cimento de fosfato de cálcio submetidos a três técnicas de esterelização. Rev Fac Odontol Passo Fundo 2008; 13: 27-32.
Furst W, Banerjee A, Redl H. Comparison of structure, strength and cytocompatibility of a fibrin matrix supplemented either with tranexamic acid or aprotinin. J Biomed Mater Res B Appl Biomater 2007; 82(1):109-14.
Hermeto LC, Rossi Rd, Pádua SB, Pontes ER, Santana AE. Comparative study between fibrin glue and platelet rich plasma in dogs skin grafts. Acta Cir Bras 2012; 27(11):789-94.
Isogai N, Landis WJ, Mori R, Gotoh Y, Gerstenfeld LC, Upton J, et al. Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells. Plast Reconstr Surg 2000; 105(3):953-63.
Le Guéhennec L, Layrolle P, Daculsi G. A review of bioceramics and fibrin sealant. Eur Cell Mater 2004; 13:1-10.
Okamoto T, Alves-Rezende MCR, Okamoto AC, Buscariolo IA, Garcia Jr IR. Osseous regeneration in the presence of fibrin adhesive material(Tissucol) and epsilon-aminocaproic acid (EACA). Braz Dent J 1995; 6(2):77-83.
Neiva RF, Tsao Y, Eber R, Shotwell J, Billy E, Wang HL. Effects of a putty-form hydroxyapatite matrix combined with the synthetic cell-binding peptide p-15 on alveolar ridge preservation. J Periodontol 2008; 79: 291-9.
Carlo EC, Borges APB, Vargas MIV, Martinez MM, Eleotério RB, Dias AR, et al. Resposta tecidual ao compósito 50% hidroxiapatita: 50% poli-hidroxibutirato para substituição óssea em coelhos. Arq Bras Med Vet Zootec 2009; 61:844- 52.
Perka C, Schultz O, Spitzer RS, Lindenhayn K, Burmester GR, Sittinger M. Segmental bone repair by tissue-engineered periosteal cell transplants with bioresorbable fleece and fibrin scaffolds in rabbits. Biomaterials 2000; 21: 1145-53.
Yamada Y, Boo JS, Ozawa R, Nagasaka T, Okazaki Y, Hata K, et al. Bone regeneration following injection of mesenchymal stem cells and fibrin glue with a biodegradable scaffold. J Craniomaxillofac Surg 2003; 31:27-33.
You TM, Choi BH, Zhu SJ, Jung JH, Lee SH, Huh JY, Lee HJ, Li J. Platelet-enriched fibrin glue and platelet-rich plasma in the repair of bone defects adjacent to titanium dental implants. Int J Oral Maxillofac Implants 2007; 22(3):417-22.
ten Hallers EJ, Jansen JA, Marres HA, Rakhorst G, Verkerke GJ. Histological assessment of titanium and polypropylene fiber mesh implantation with and without fibrin tissue glue. J Biomed Mater Res A 2007; 80(2):372-80.
Cox S, Cole M, Mankarious S, Tawil N. Effect of tranexamic acid incorporated in fibrin sealant clots on the cell behavior of neuronal and nonneuronal cells. J Neurosci Res 2003 15;72(6):734-46.
Okamoto T, Okamoto R, Alves-Rezende MCR, Gabrielli MF: Interference of the blood clot on granulation tissue formation after tooth extraction. Histomorphological study in rats. Braz Dent J 1994; 5(2):85-92.
An SH, Matsumoto T, Miyajima H, Nakahira A, Kim KH, Imazato S. Porous zirconia/hydroxyapatite scaffolds for bone reconstruction. Dent Mater 2012; 28(12):1221-31
Jensen T, Baas J, Dolathshahi-Pirouz A, Jacobsen T, Singh G, Nygaard JV, Foss M, Bechtold J, Bünger C, Besenbacher F, Søballe K. Osteopontin functionalization of hydroxyapatite nanoparticles in a PDLLA matrix promotes bone formation. J Biomed Mater Res A 2011;99(1):94-101
Mistry S, Kundu D, Datta S, Basu D. Effects of bioactive glass, hydroxyapatite and bioactive glass - Hydroxyapatite composite graft particles in the treatment of infrabony defects. J Indian Soc Periodontol 2012; 16(2): 241-6.
Nakamura K, Koshino T, Saito T. Osteogenic response of the rabbit femur to a Hydroxyapatite thermal decomposition product fibrin sealant mixture. Biomaterials 1998;19: 1901-7.
Zambuzzi WF, Oliveira RC, Alanis D, Menezes R, Letra A, Cestari TM, et al. Microscopic analysis of porous microgranular bovine anorganic bone implanted in rat subcutaneous tissue. J Appl Oral Sci. 2005 ;13(4):382-6.
Hubbard W. Physiological calcium phosphates as orthopedic biomaterials. Milwaukee, 1974. 222 f. Thesis (PhD) - Marquette University, 1974.
Webster TJ, Schadler LS, Siegel RW, Bizios R. Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin. Tissue Eng 2001, 7(3): 291-301
Salih V, Georgiou G, Knowles JC, Olsen I. Glass reinforced hydroxyapatite for hard tissue surgery--part II: in vitro evaluation of bone cell growth and function. Biomaterials 2001; 22:2817-24.
Wittkampf AR. Fibrin glue as cement for HA-granules. J Cranio-Maxillofacial Surg 1989; 17: 179–81.
Claro APRA, de Oliveira JAG, Escada AL do A, Carvalho LMF, Louzada MJQ, Rezende MCRA. Histological analysis of the osseointegration of Ti-30Ta dental implants after surface treatment. In: Ochsner A et al. editors Characterization and Development of Biosystems and Biomaterials. Advanced Structured Materials. Springer-Verlag Berlin Heidelberg; 29, 2013, p 175-181.
