Adverse Reactions Associated with Benzodiazepines use to Anxiety Control in Dental Practice: a Literature Review

Authors

  • André Ricardo Rodrigues Julio Cirurgião-Dentista. Universidade Federal do Piauí, UFPI 64202-020 Teresina - PI, Brasil
  • Joelma Silva de Almeida Cirurgiã-Dentista e Mestre em Odontologia. Universidade Federal do Piauí, UFPI 64202-020 Teresina - PI, Brasil https://orcid.org/0000-0003-4232-0494
  • Daniel Ramon Oliveira Dantas Léllis Farmacêutico especialista em Farmacologia e Farmácia Clínica. Instituto Brasil de Pós Graduação, Capacitação e Assessoria, iBras 64045-385 Teresina-PI, Brasil
  • Lyzia Vitória Mendes Rezende Cirurgiã-Dentista, Mestranda, PPGO UFPI - Programa de Pós-graduação em Odontologia da Universidade Federal do Piauí (UFPI) 64049-550 Teresina – PI, Brasil https://orcid.org/0000-0002-8644-0802

DOI:

https://doi.org/10.21270/archi.v11i2.5384

Keywords:

Anxiety, Conscious Sedation, Adverse Reaction

Abstract

Introduction: For the care of anxious patients during dental treatment, the use of benzodiazepines is a method of pharmacological control that allows a comfortable and safe care. Through this method, minimal sedation of consciousness can be obtained, but adverse effects can be associated with the use of these drugs. Objective: to carry out a literature review identifying the possible adverse effects triggered by benzodiazepines used as a method of pharmacological control of anxiety in dental practice. Material and method: The selected and analyzed articles were obtained through the Scielo, PubMed and CAPES Periodical databases. Results / Discussion: The adverse effects to the use of benzodiazepines for minimal sedation have a low occurrence, and the most recognized by the literature are: anterograde amnesia, sexual hallucinations, drowsiness, in addition to paradoxical effects such as excitement, aggressiveness and irritability. Conclusion: It is important that the dentist is trained to use the use of benzodiazepines in a sensible and responsible manner, selecting the most appropriate drug for the appropriate situation.

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References

Andrade, E. D. Terapêutica Medicamentosa em Odontologia.3.ed. São Paulo: Artes Médicas; 2013.

American Dental Association. Guidelines for the use of sedation and general anesthesia by dentists.Chicago: ADA; 2007.

Cogo K, Bergamaschi CC, Yatsuda R, Volpato MC, Andrade ED. Sedação consciente com benzodiazepínicos em odontologia Rev Odontol Univ Cid São Paulo. 2006;18(2):181-8.

Oliveira MC, Aleixo RQ, Rodrigues MTV. Uso de benzodiazepínicos em cirurgia bucomaxilofacial.Saber Cient. 2010;1:53-67.

Frazão VT, Filippi AC. Midazolam: aspectos farmacológicos e seu uso em diferentes níveis de sedação. Rev Saúde. 2020;11(1):36-41.

Brunton, L.L; Chabner BA; Knollmann BC. As Bases Farmacológicas da Terapêutica de Goodman & Gilman.12.ed. Porto Alegre: AMGH; 2012

Beracochea D. Anterograde and Retrograde Effects on Memory. ScientificWorldJournal. 2006;6:1460-65

Korpi ER, Grunder G, Luddens H. Drug interactions at GABA(A) receptors. Prog Neurobiol. 2002;67:113-59.

Savic MM, Obradovic D.I, Ugresic N.D, Bokonjic D.R. Memory effects of benzodiazepines: memory stages and types versus binding-site subtypes. Neural Plast. 2005;12:289-98

Garip H, Gurkan Y, Toker K. A comparison of midazolam and midazolam with remifentanil for patient-controlled sedation during operations on third molars. Br J Oral Maxillofac Surg. 2007;45(3):212-16.

Becker D. E. Adverse drug reactions in dental practice. Anesth. Prog. 2014;61:26-34.

Haas DA. Oral sedation in dental practice. Royal College of DentalSurgeons of Ontario. 2015.

Alzahrani A, Wyne A. Use of oral midazolam sedation in pediatric dentistry: a review, Pakistan Oral Dent J. 2012;32(3):444-55,.

Cheng X, Chen Z, Zhang L, Xu P, Qin F, Jiao X et al. Efficacy and Safety of Midazolam Oral Solution for Sedative Hypnosis and Anti-anxiety in Children: A Systematic Review and Meta-Analysis.Front Pharmacol.2020;11:225.

Silva TCG, Santos MPPT, Abrahão GS, Abrahão DP. Análise dos sinais vitais após administração de midazolam e cloridrato de ondansetrona em pacientes submetidos a cirurgia de catarata. JCBS. 2017;2(3):95-9.

Lucatto FN, Ferreira RL, Dezan PM, Scorsi NR, Jacomassi BR, Gomes EAH et al. Sedação medicamentosa com midazolam em pacientes portadores de necessidades especiais. Arch Health Invest. 2017;6(Spec Iss 2):268.

Sharma V, Singh A, Sharma P, Kaur S. Comparative Study Between Oral Lorazepam and Diazepam as Sedation in Oral and Maxillofacial Surgery. J Maxillofac Oral Surg. 2019;18(2):256-59.

Gallagher C. Benzodiazepines: Sedation and Agitation.Dent Update. 2016;43(1):83-9.

Saias T, Gallarda T. Paradoxical aggressive reactions to benzodiazepine use: a review. Encephale. 2008;34(4):330-36.

Fiorillo L. Conscious Sedation in Dentistry. Medicina (Kaunas). 2019;55(12):778.

Published

2021-11-04

How to Cite

Julio, A. R. R., Almeida, J. S. de ., Léllis, D. R. O. D., & Rezende, L. V. M. (2021). Adverse Reactions Associated with Benzodiazepines use to Anxiety Control in Dental Practice: a Literature Review. ARCHIVES OF HEALTH INVESTIGATION, 11(2), 379–382. https://doi.org/10.21270/archi.v11i2.5384

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Original Articles