Helicobacter pylori em boca: epidemiologia e associação com doenças bucais

Authors

  • Elerson Gaetti-Jardim Jr
  • Ana Cláudia Okamoto
  • Christiane Marie Schweitzer
  • Maurício Fabiano Pereira
  • Ana Paula Miranda Vieira
  • Renato Salviato Fajardo

Abstract

A associação de Helicobacter pylori com diferentes enfermidades gástricas vem sendo continuamente discutida na literatura, sendo que nos últimos 20 anos um grande volume de publicações destinou-se à caracterizar os diferentes nichos ecológicos e habitats desse patógeno, sendo a boca um possível habitat para essa bactéria. O presente estudo objetivou, por meio de revisão de literatura, discutir a epidemiologia e associação desse organismo, como parte da microbiota suplementar ou transitória da boca, à doença periodontal. Para tanto, uma extensa revisão de literatura contemplando o período de 1990-2014 foi realizada junto a diferentes bases de dados, obtendo-se 5024 artigos relativos à transmissão e epidemiologia de H. pylori, em inglês e português. Os artigos foram selecionados segundo os critérios de exclusão e inclusão e seus dados foram tabulados e analisados. A despeito da grande heterogeneidade da literatura consultada, verificou-se que esse microaerófilo apresenta distribuição mundial, mesmo na boca, a qual se comporta como reservatório para a reinfecção gástrica. O papel da higiene bucal e das enfermidades periodontais na distribuição desse microrganismo não está esclarecido, mas a maioria dos estudos dão suporte à hipótese de que o biofilme bucal e a inflamação periodontal facilitam a instalação desse patógeno na boca. Estudos sugerem que esse microrganismo possa colaborar como fator predisponente para o câncer bucal.

Descritores: Helicobacter; Transmissão; Epidemiologia; Doenças periodontais; Gastrite; Neoplasias bucais.

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References

Correa P. Helicobacter pylori as a pathogen and carcinogen. J Physiol Pharmacol. 1997;48 Suppl 4:19-24.

Song MY, Su HJ, Zhang L, Ma JL, Li JY, Pan KF et al. Genetic polymorphisms of miR-146a and miR-27a, H. pylori infection, and risk of gastric lesions in a Chinese population. 2013; PLoS One 8: e61250. doi: 10.1371/journal.pone.0061250

Fagoonee S, De Angelis C, Elia C, Silvano S, Oliaro E, Rizzetoo M et al. Potential link between Helicobacter pylori and ischemic heart disease: does the bacterium elicit thrombosis? Minerva Med. 2010;101:121-125.

Jafarzadeh A, Esmaeeli-Nadimi A, Nemati M, Tahmasbi M, Ahmadi P. Serum concentrations of Helicobacter pylori IgG and the virulence factor CagA in patients with ischaemic heart disease. East Mediterr Health J. 2010;16:1039-44.

Ojetti V, Pellicano R, Fagoonee S, Migneco A, Berrutti M, Gasbarrini A. Helicobacter pylori infection and diabetes. Minerva Med. 2010;101:115-109.

Krajden S, Fuksa M, Anderson J, Kempston J, Boccia

A, Petrea C, et al. Examination of human stomach biopsies, saliva, and dental plaque for Campylobacter pylori. J Clin Microbiol. 1989;27:1397-1398.

Chow TK, Lambert JR, Wahlqvist ML, Hsu-Hage BH. Helicobacter pylori in Melbourne Chinese immigrants: evidence for oral-oral transmission via chopsticks. J Gastroenterol Hepatol. 1995;10:562-569.

Cellini L, Grande R, Artese L, Marzio L. Detection of Helicobacter pylori in saliva and esophagus. New Microbiol. 2010;33:351-357.

Zou QH, Li RQ. Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis. J Oral Pathol Med. 2011;40:317-324.

Mégraud F. Transmission of Helicobacter pylori: faecal-oral versus oral-oral route. Aliment Pharmacol Ther. 1995; 9 Suppl 2:85-91.

Yee KC, Wei MH, Yee HC, Everett KD, Yee HP, Hazeki-Talor N. A screening trial of Helicobacter pylori-specific antigen tests in saliva to identify an oral infection. Digestion. 2013;87:163-169.

Cecchini MP, Pellegrini C, Bassetto MA, Osculati F, Sbarbati A, Marcolini L, et al. Might Helicobacter pylori infection be associated with distortion on taste perception? Medical Hypotesis. 2013;81(3):496-499.

Al Asqah M, Al Hamoudi N, Anil S, Al Jebreen A, Al-Hamoudi WK. Is the presence of Helicobacter pylori in dental plaque of patients with chronic periodontitis a risk factor for gastric infection? Can J Gastroenterol. 2009;23: 177-179.

Miyabayashi H, Furihata K, Shimizu T, Ueno I, Akamatsu T. Influence of oral Helicobacter pylori on the success of eradication therapy against gastric Helicobacter pylori. Helicobacter. 2000;5:30-37.

Zaric S, Bojic B, Jankovic Lj, Dapcevic B, Popovic B, Cakic S, Milasin J. Periodontal therapy improves gastric Helicobacter pylori eradication. J Dent Res. 2009;88:946-950.

Assumpção MB, Martins LC, Melo Barbosa HP, Barile KA, de Almeida SS, Assumpção PP, et al. Helicobacter pylori in dental plaque and stomach of patients from Northern Northern Brazil. World J Gastroenterol. 2010;16:3033-3039.

Wichelhaus A, Brauchli L, Song Q, Adler G, Bode G. Prevalence of Helicobacter pylori in the adolescent oral cavity: dependence on orthodontic therapy, oral flora and hygiene. J Orofac Orthop. 2011;72:187-195.

Song H-Y, Li Y. Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori? World J Gastroenterol. 2013;19(39):6645-6650.

Shmuely H, Yahav J, Samra Z, Chodick G, Koren R, Niv Y, et al. Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor. Mol Nutr Food Res.2007;51:746-751.

Jia CL, Jiang GS, Li CH, Li CR. Effect of dental plaque control on infection of Helicobacter pylori in gastric mucosa. Tex Dent J. 2012;129:1069-1073.

Czesnikiewicz-Guzik M, Loster B, Bielanski W, Guzik TJ, Konturek PC, Zapala J, et al. Implications of oral Helicobacter pylori for the outcome of its gastric eradication therapy. J Clin Gastroenterol. 2007;41:145-151.

Martinez-Gomiz J, Diouf A, Lakhssasi N, Sixou M. Absence of Helicobacter pylori in the oral cavity of 10 nondyspeptic subjects demonstrated by real-time polymerase chain reaction. Oral Microbiol Immunol. 2006;21:407-10.

Bago I, Bago J, Plecko V, Aurer A, Majstorovic K, Budimir A. The effectiveness of systemic eradication therapy against oral Helicobacter pylori. J Oral Pathol Med. 2011;40:428-432.

Andersen RN, Ganeshkumar N, Kolenbrander PE. Helicobacter pylori adheres selectively to Fusobacterium spp. Oral Microbiol Immunol. 1998;13:51-54.

Souto R, Colombo AP. Detection of Helicobacter pylori by polymerase chain reaction in the subgingival biofilm and saliva of non-dyspeptic periodontal patients. J Periodontol. 2008;79:97-103.

Riggio MP, Lennon A. Identification by PCR of Helicobacter pylori in subgingival plaque of adult periodontitis patients. J Med Microbiol. 1999;48: 317-322.

Avcu N, Avcu F, Beyan C, Ural A, Kaptan K, Ozyurt M. The relationship between gastric-oral Helicobacter pylori and oral hygiene in patients with vitamin B-12 deficiency anemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:166-169.

Oshowo A, Gillam D, Botha A, Turnio M, Holton J, Boulos P. Helicobacter pylori: the mouth, stomach and gut axis. Ann Periodontol. 1998;3:276-280.

Sayed MM, Ibrahim WA, Abdel-Bary SA, Abdelhakam SM, El-Masry SA, Ghoraba D. Salivary PCR detection of Helicobacter pylori DNA in Egyptian patients with dyspepsia. Egyptian Journal of Medical Human Genetics. 2011;12:211-216.

Rasmussen LT, Labio RW, Gatti LL, Silva LC, Queiroz VF, Smith MA et al. Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients. Mem Inst Oswaldo Cruz. 2010;105(3):326-330.

Román-Román A, Giono-Cerezo S, Camorlinga-Ponce M, Martínez-Carrillo D N, Loaiza-Loeza L, Fernández-Tilapa G. vacA genotypes of Helicobacter pylori in the oral cavity and stomach of patients with chronic gastritis and gastric ulcer. Enferm Infecc Microbiol Clin. 2013;31(3):130-135.

Butt AK, Khan AA, Bedi R. Helicobacter pylori in dental plaque of Pakistanis. J Int Acad Periodontol. 1999;1:78-82.

Siddiq M, Rehman H, Mahmood A. Evidence of Helicobacter pylori infection in dental plaque and gastric mucosa. J Coll. Physicians Surg Pak. 2004;14:205-207.

Chaudhry S, Khan AA, Butt AK, Idrees M, Izhar M, Iqbal AH. Helicobacter pylori in Dental Plaque; Is it related to brushing frequency, plaque load and oral health status? Journal of the College of Physicians and Surgeons Pakistan. 2011;21(10):589-592.

Li C, Musich PR, Ha T, Ferguson DA Jr, Patel NR, Chi DS, et al. High prevalence of Helicobacter pylori in saliva demonstrated by a novel PCR assay. J Clin Pathol. 1995;48:662-666.

Wang J, Chi DS, Laffan JJ, Li C, Ferguson DA Jr, Litchfield P, et al Comparison of cytotoxin genotypes of Helicobacter pylori in stomach and saliva. Dig Dis Sci. 2002;47:1850-1856.

Tiwari SK, Khan AA, Ahmed KS, Ali SM, Ahmed I, Habeeb A, et al. Polymerase chain reaction based analysis of the cytotoxin associated gene pathogenicity island of Helicobacter pylori from saliva: an approach for rapid molecular genotyping in relation to disease status. J Gastroenterol Hepatol. 2005;20:1560-1566.

Silva DG, Tinoco BEM, Rocha GA, Rocha AMC, Guerra JB, Saraiva IEB et al. Helicobacter pylori transiently in the mouth may participate in the transmission of infection. Mem Inst Oswaldo Cruz. 2010;105(5):657-660.

Rocha GA, Rocha AM, Silva LD, Santos A, Bocewicz AC, Queiroz RD et al. Transmission of Helicobacter pylori infection in families of preschool-aged children from Minas Gerais, Brazil. Trop Med Int Health. 2003;, 8(11):987-991.

Sambashivaiah S, Bilichodmath S, Nanjaiah N, Kulal R. Helicobacter pylori in periodontal pockets of chronic periodontitis patients with and without type II diabetes mellitus: a randomized controlled trial. Microbiol. Res. 2011;3(12):45-48.

Al-Ahmad A, Kürschner A, Weckesser S, Wittmer A, Rauberger H, Jakob T, et al. Is Helicobacter pylori resident or transient in the human oral cavity? Journal of Medical Microbiology. 2012;61:1146-1152.

Zaric S, Bojic B, Jankovic Lj, Dapcevic B, Popovic B, Cakic S, Milasin J. Periodontal therapy improves gastric Helicobacter pylori eradication. J Dent Res. 2009;88:946-950.

Silva DG, Stevens RH, Macedo JMB, Veerman E, Tinoco EMB. Detection of cytotoxin genotypes of Helicobacter pylori in stomach, saliva and dental plaque. Arch Oral Biol. 2009;54:684-688.

Jia CL, Jiang GS, Li CH, Li CR. Effect of dental plaque control on infection of Helicobacter pylori in gastric mucosa. J Periodontol. 2009;80:1606-1609.

Navabi N, Aramon M, Mirzazadeh A. Does the presence of the Helicobacter pylori in the dental plaque associate with its gastric infection? A meta-analysis and systematic review. Dent Res J. 2011;8(4):172-180.

Umeda M, Kobayashi H, Takeuchi Y, Hayashi J, Morotome-Hayashi Y, Yano K, Aoki A, Ohkusa T, Ishikawa I. High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients. J Periodontol. 2003;74:129-134.

Saxena PK, Aziz AS, Kalekar MG, Mol JPM, Suryakar AN, Tabita B, et al. Presence of Helicobacter pylori detected by PCR in saliva of male smokers and non-smokers with chronic periodontitis. British Journal of Medicine & Medical Research. 2013;3(2): 329-340.

Tsuji S, Kawai N, Tsuji M, Kawano S, Hori M. Review article: inflammation-related promotion of gastrointestinal carcinogenesis – a perigenetic pathway. Aliment Pharmacol Ther. 2003;18 Suppl 1:82-89.

Suganuma M, Yamaguchi K, Ono Y, Matsumoto H, Hayashi T, Ogawa T, et al. TNF-α inducing protein, a carcinogenic factor secreted from H. pylori, enters gastric cancer cells. Int J Cancer. 2008;123:117-122.

Bagaitkar J, Demuth DR, Scott DA. Tobacco use increases susceptibility to bacterial infection. Tobacco induced diseases. 2008;4(12):4-12.

Boylan MR, Khalili H, Huang ES, Michaud DS, Izard J, Joshipura KJ, et al. Prospective study of periodontal disease and risk of gastric and duodenal ulcer in male health professional. Clin Transl Gastroenterol. 2014;5(49):

Da Silva M K, Terezan M L F, Fischer RG. Associação da halitose com a presença de Helicobacter pylori no biofilme dental supragengival em pacientes com doença periodontal – um estudo piloto. Braz J Periodontol. 2012; 22(01):63-68.

Liu Y, Lin H, Bai Y, Qin X, Zheng X, Sun Y, Zhang. Study on the relationship between Helicobacter pylori in the dental plaque and the occurrence of dental caries or oral hygiene index. Helicobacter. 2008;13:256-260.

Liu P, Yue J, Han S, Deng T, Fu C, Zhu G, et al. A cross-sectional survey of dental caries, oral hygiene, and Helicobacter pylori infection in adults. Asia Pac J Public Health. 2013;25(4 Suppl):49S-56S. doi: 10.1177/1010539513495555.

Namiot DB, Leszczyńska K, Namiot Z, Chilewicz M, Bucki R, Kemona A. The occurrence of Helicobacter pylori antigens in dental plaque; an association with oral health status and oral hygiene practices. Advances in Medical Sciences. 2010;55(2):167-171.

Nguyen AMH, El-Zaatari FAK, Graham DY. Helicobacter pylori in the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:705-709.

Özdemir A, Mas MR, Sahin S. Detection of Helicobacter pylori colonization in dental plaques and tongue scrapings of patients with chronic gastritis. Quintessence Int. 2001;32:131-134.

Bürgers R, Schneider-Brachert W, Reischl U, Behr A, Hiller KA, Lehn N, et al. Helicobacter pylori in human oral cavity and stomach. Eur J Oral Sci. 2008;116:297-304.

Asikainen S, Chen C, Slots J. Absence of Helicobacter pylori in subgengival samples determined by polymerase chain reaction. Oral Microbiol Immunol. 1994;9:318-320.

Anand PS, Nandakumar K, Shenoy KT. Are dental plaque, poor oral hygiene, and periodontal disease associated with Helicobacter pylori infection? J Periodontol. 2006;77(4):692-698.

Dye BA, Kruszon-Moran D, McQuillan G. The relationship between periodontal disease attributes and Helicobacter pylori infection among adults in the United States. Am J Public Health. 2002;92:1809-1815.

Rôças IN, Siqueira Jr. J. Searching for Helicobacter pylori and Chlamydia pneumoniae in primary endodontic infections. European Journal of Dentistry. 2012;6:158-162.

Satheeshkumar PS. Oral Helicobacter pylori infection and the risk of oral cancer. Oral Oncology. 2013;49:20-21.

Dayama A, Srivastava1 V, Shukla M, Singh R, Pandey M. Helicobacter pylori and Oral Cancer: Possible association in a preliminary case control study. Asian Pacific Journal of Cancer Prevention. 2011;12:1333-1336.

Published

2014-05-05

How to Cite

Gaetti-Jardim Jr, E., Okamoto, A. C., Schweitzer, C. M., Pereira, M. F., Vieira, A. P. M., & Fajardo, R. S. (2014). Helicobacter pylori em boca: epidemiologia e associação com doenças bucais. ARCHIVES OF HEALTH INVESTIGATION, 3(2). Retrieved from https://archhealthinvestigation.com.br/ArcHI/article/view/670

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