Osteonecrosis de los Maxilares Asociada a Medicamentos con Posible Sepsis Relacionada

Autores/as

  • Raquel D’Aquino Garcia Caminha Master’s degree, Applied Dental Sciences Program,Bauru School of Dentistry (FOB), University of São Paulo (USP)
  • Vivian Palata Viola Master’s degree, Applied Dental Sciences Program, Bauru School of Dentistry (FOB), University of São Paulo (USP) https://orcid.org/0000-0002-1267-1712
  • Flávia Cristina Costa Bachelor's Degree in Dentistry, Bauru School of Dentistry (FOB), University of São Paulo (USP)
  • Ana Livia do Amaral Master’s degree, Applied Dental Sciences Program, Bauru School of Dentistry (FOB), University of São Paulo (USP)
  • Gustavo Valerio Maluf PhD, Applied Dental Sciences Program, Bauru School of Dentistry (FOB), University of São Paulo (USP) https://orcid.org/0000-0001-5507-1824
  • Paulo Sérgio da Silva Santos Full Professor of Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry (FOB), University of São Paulo (USP) https://orcid.org/0000-0002-0674-3759

DOI:

https://doi.org/10.21270/archi.v14i1.6293

Palabras clave:

Difosfonatos, Cirugía Bucal, Osteonecrosis, Sepsis, Plasma Rico en Plaquetas

Resumen

La sepsis se considera un síndrome que se produce como resultado de la liberación de varias citocinas y otros mediadores en respuesta a un proceso infeccioso. Se desarrolla de forma potencialmente grave y tiene una elevada tasa de mortalidad. El diagnóstico de la osteonecrosis de mandíbula relacionada con la medicación (MRONJ) es cada vez más frecuente, y es una comorbilidad que presenta un alto riesgo de desarrollo de infección. Los informes de casos que relacionan el diagnóstico de sepsis con MRONJ son escasos en la literatura, y la necesidad de actualizaciones para un diagnóstico precoz y tratamientos eficaces son cruciales en estas afecciones.

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Citas

1. Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D. American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update. J Oral Maxillofac Surg. 2022;80(5):920-943.

2. Caminha R D'A-G, Alcantara PL, Carvalho CG, Reia VCB, Capelozza ALA, Santos PSS. The impact of medication-related osteonecrosis of the jaws on the quality of life in cancer patients. J Clin Exp Dent. 2020;12(8):e725-e729.

3. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg. 2014;72(10):1938-56.

4. Yamashiro K, Sato A, Okazari F, Nakano M, Sawaki K, Hirata Y, et al. Medication-related osteonecrosis of the jaws caused lethal sepsis in an edentulous patient with multiple systemic factors. Clin Case Rep. 2016;5(2):97-103.

5. Viviano M, Addamo A, Cocca S. A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report. J Korean Assoc Oral Maxillofac Surg. 2017;43(4):272-275.

6. Yarom N, Shapiro CL, Peterson DE, Poznak CHV, Bohlke K, Ruggiero SL, et al. Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline. J Clin Oncol. 2019;37(25):2270-2290.

7. Vincent J-L. Sepsos definitions. Lancet Infect Dis. 2002;2(3):135.

8. Machado FR, Ferreira EM, Schippers P, de Paula IC, Saes LSV, de Oliveira Jr FI, et al. Implementation of sepsis bundles in public hospitals in Brazil: a prospective study with heterogeneous results. Crit Care. 2017;21(1):268

9. Kaehling CH, Streckbein PH, Schmermund D, Henrich M, Burchert D, Gattenloehner S, Howaldt H-P, Wilbrand J-F. Lethal cervical abscess following bisphosphonate related osteonecrosis of the jaw. J Craniomaxillofac Surg. 2014;42(7):1203-6.

10. Qaisi M, Hargett J, Loeb M, Brown J, Caloss R. Denosumab Related Osteonecrosis of the Jaw with Spontaneous Necrosis of the Soft Palate: Report of a Life Threatening Case. Case Rep Dent. 2016;2016:5070187.

11. Fliefel R, Tröltzsch M, Kühnisch J, Ehrenfeld M, Otto S. Treatment strategies and outcomes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with characterization of patients: a systematic review. Int J Oral Maxillofac Surg. 2015;44(5):568-85.

12. Martins MAT, Giglio A, Martins MD, Pavesi VCS, Lascala CA. Bisphosphonate-associated jaws osteonecrosis: an important complication of oncology treatment. Rev. Bras. Hematol. Hemoter. 2009;31(1):41-46.

13. Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws--2009 update. J Oral Maxillofac Surg. 2009;67(5 Suppl):2-12.

14. Khan A, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, et al.Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30(1):3-23.

15. Maluf G, Jardim RC, Santos PSS. Use of leukocyte-and platelet-rich fibrin in the treatment of medication-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2018;76(1):88-96.

16. Mourão CFAB, Valiense H, Melo ER, Mourão NBMF, Maia MD-C. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir. 2015;42(6):421-423.

17. Soydan SS, Uckan S. Management of bisphosphonate-related osteonecrosis of the jaw with a platelet-rich fibrin membrane: technical report. J Oral Maxillofac Surg. 2014;72(2):322-6.

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Publicado

2025-01-31

Cómo citar

Caminha, R. D. G., Viola, V. P., Costa, F. C., Amaral, A. L. do, Maluf, G. V., & Silva Santos, P. S. da. (2025). Osteonecrosis de los Maxilares Asociada a Medicamentos con Posible Sepsis Relacionada. ARCHIVES OF HEALTH INVESTIGATION, 14(1), 102–105. https://doi.org/10.21270/archi.v14i1.6293

Número

Vol. 14 Núm. 1 (2025)

Sección

Original Articles